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Mouse Anti-OVGP1 Recombinant Antibody (3F9) (CBMAB-O0776-CQ)

This product is a mouse antibody that recognizes OVGP1. The antibody 3F9 can be used for immunoassay techniques such as: ELISA, WB.
See all OVGP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3F9
Antibody Isotype
IgG2a, Κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, Κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
oviductal glycoprotein 1, 120kDa
Introduction
This gene encodes a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located within threonine, serine, and proline-rich tandem repeats. The gene is similar to members of the mucin and the glycosyl hydrolase 18 gene families. Regulation of expression may be estrogen-dependent. Gene expression and protein secretion occur during late follicular development through early cleavage-stage embryonic development. The protein is secreted from non-ciliated oviductal epithelial cells and associates with ovulated oocytes, blastomeres, and spermatozoan acrosomal regions.
Entrez Gene ID
5016
UniProt ID
Q12889
Alternative Names
Oviductal Glycoprotein 1; Oviductin; Estrogen-Dependent Oviduct Protein; Oviductal Glycoprotein 1, 120kDa; Mucin 9; MUC9; OGP
Function
Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development.
Biological Process
Carbohydrate metabolic processIEA:InterPro
Chitin catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Female pregnancyManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of binding of sperm to zona pellucidaIEA:Ensembl
Single fertilizationIEA:UniProtKB-KW
Cellular Location
Cytoplasmic vesicle, secretory vesicle
Secretory granules.

Yamatoya, K., Kurosawa, M., Hirose, M., Miura, Y., Taka, H., Nakano, T., ... & Araki, Y. (2024). The fluid factor OVGP1 provides a significant oviductal microenvironment for the reproductive process in golden hamster. Biology of Reproduction, 110(3), 465-475.

Wang, J., Pan, Y., Wang, M., Xu, R., Han, X., Ma, R., ... & Yu, S. (2023). Follicular fluid exosomes regulate OVGP1 secretion in yak oviduct epithelial cells via autophagy in vitro. Journal of Cellular Physiology, 238(5), 1020-1035.

Zhao, Y., Vanderkooi, S., & Kan, F. W. (2022). The role of oviduct-specific glycoprotein (OVGP1) in modulating biological functions of gametes and embryos. Histochemistry and Cell Biology, 157(3), 371-388.

Vanderkooi, S. C., Zhao, Y., Lima, P. D., & Kan, F. W. (2022). Recombinant human OVGP1 increases intracellular calcium and further potentiates the effects of progesterone on human sperm. Journal of Assisted Reproduction and Genetics, 39(10), 2287-2301.

Yamatoya, K., Kurosawa, M., Hirose, M., Miura, Y., Taka, H., Nakano, T., ... & Araki, Y. (2022). OVGP1 is an oviductal fluid factor essential particularly for early embryonic development in golden hamsters. bioRxiv, 2022-10.

Zhao, Y., & Kan, F. W. (2019). Human OVGP1 enhances tyrosine phosphorylation of proteins in the fibrous sheath involving AKAP3 and increases sperm-zona binding. Journal of Assisted Reproduction and Genetics, 36, 1363-1377.

Choudhary, S., Janjanam, J., Kumar, S., Kaushik, J. K., & Mohanty, A. K. (2019). Structural and functional characterization of buffalo oviduct-specific glycoprotein (OVGP1) expressed during estrous cycle. Bioscience Reports, 39(12), BSR20191501.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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