Mouse Anti-OVGP1 Recombinant Antibody (CBXO-0098) (CBMAB-O0777-CQ)

Name: Mouse Anti-OVGP1 Recombinant Antibody (CBXO-0098)
SKU: CBMAB-O0777-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXO-0098

Application

S-ELISA, WB, ELISA

Immunogen

OVGP1 (NP_002548.3, 579 a.a.-677 a.a) partial Recombinant protein with GST tag

Specificity

Human

Antibody Isotype

IgG2a, Κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

oviductal glycoprotein 1, 120kDa

Introduction

This gene encodes a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located within threonine, serine, and proline-rich tandem repeats. The gene is similar to members of the mucin and the glycosyl hydrolase 18 gene families. Regulation of expression may be estrogen-dependent. Gene expression and protein secretion occur during late follicular development through early cleavage-stage embryonic development. The protein is secreted from non-ciliated oviductal epithelial cells and associates with ovulated oocytes, blastomeres, and spermatozoan acrosomal regions.

Entrez Gene ID

5016

UniProt ID

Q12889

Alternative Names

Oviductal Glycoprotein 1; Oviductin; Estrogen-Dependent Oviduct Protein; Oviductal Glycoprotein 1, 120kDa; Mucin 9; MUC9; OGP

Function

Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development.

Biological Process

Carbohydrate metabolic processIEA:InterPro
Chitin catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Female pregnancyManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of binding of sperm to zona pellucidaIEA:Ensembl
Single fertilizationIEA:UniProtKB-KW

Cellular Location

Cytoplasmic vesicle, secretory vesicle
Secretory granules.

Yamatoya, K., Kurosawa, M., Hirose, M., Miura, Y., Taka, H., Nakano, T., ... & Araki, Y. (2024). The fluid factor OVGP1 provides a significant oviductal microenvironment for the reproductive process in golden hamster. Biology of Reproduction, 110(3), 465-475.

Wang, J., Pan, Y., Wang, M., Xu, R., Han, X., Ma, R., ... & Yu, S. (2023). Follicular fluid exosomes regulate OVGP1 secretion in yak oviduct epithelial cells via autophagy in vitro. Journal of Cellular Physiology, 238(5), 1020-1035.

Zhao, Y., Vanderkooi, S., & Kan, F. W. (2022). The role of oviduct-specific glycoprotein (OVGP1) in modulating biological functions of gametes and embryos. Histochemistry and Cell Biology, 157(3), 371-388.

Vanderkooi, S. C., Zhao, Y., Lima, P. D., & Kan, F. W. (2022). Recombinant human OVGP1 increases intracellular calcium and further potentiates the effects of progesterone on human sperm. Journal of Assisted Reproduction and Genetics, 39(10), 2287-2301.

Yamatoya, K., Kurosawa, M., Hirose, M., Miura, Y., Taka, H., Nakano, T., ... & Araki, Y. (2022). OVGP1 is an oviductal fluid factor essential particularly for early embryonic development in golden hamsters. bioRxiv, 2022-10.

Zhao, Y., & Kan, F. W. (2019). Human OVGP1 enhances tyrosine phosphorylation of proteins in the fibrous sheath involving AKAP3 and increases sperm-zona binding. Journal of Assisted Reproduction and Genetics, 36, 1363-1377.

Choudhary, S., Janjanam, J., Kumar, S., Kaushik, J. K., & Mohanty, A. K. (2019). Structural and functional characterization of buffalo oviduct-specific glycoprotein (OVGP1) expressed during estrous cycle. Bioscience Reports, 39(12), BSR20191501.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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