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Mouse Anti-SAFB Recombinant Antibody (CBXS-3375) (CBMAB-S6110-CQ)

This product is a mouse antibody that recognizes SAFB. The antibody CBXS-3375 can be used for immunoassay techniques such as: IF, IHC, IP, WB.
See all SAFB antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-3375
Antibody Isotype
IgG1
Application
IF, IHC, IP, WB

Basic Information

Immunogen
Synthetic peptide corresponding to aa345-357 from human SAFB (KLH)
Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
scaffold attachment factor B
Entrez Gene ID
6294
UniProt ID
Q15424
Alternative Names
HAP; HET; SAB-B1; SAF-B; SAF-B1; SAFB1
Function
Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816).
Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241).
Thereby acts as a negative regulator of cell proliferation (PubMed:12660241).
When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity).
Biological Process
Biological Process chromatin organizationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process intracellular estrogen receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of mRNA processingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
PTM
Sumoylated by PIAS1 with SUMO1 and SUMO2/3, desumoylated by SENP1. Sumoylation is required for transcriptional repressor activity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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