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Mouse Anti-SAFB Recombinant Antibody (CBXS-5132) (CBMAB-S2350-CQ)

This product is a mouse antibody that recognizes SAFB. The antibody CBXS-5132 can be used for immunoassay techniques such as: WB, IHC-P, IF.
See all SAFB antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-5132
Antibody Isotype
IgG2b
Application
WB, IHC-P, IF

Basic Information

Immunogen
Recombinant protein corresponding to aa 111-201 of human SAFB
Specificity
Human
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
scaffold attachment factor B
Introduction
This gene encodes a DNA-binding protein which has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. The encoded protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes. It is involved in the regulation of heat shock protein 27 transcription, can act as an estrogen receptor co-repressor and is a candidate for breast tumorigenesis. This gene is arranged head-to-head with a similar gene whose product has the same functions. Multiple transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
6294
UniProt ID
Q15424
Alternative Names
Scaffold Attachment Factor B; HSP27 Estrogen Response Element-TATA Box-Binding Protein; Hsp27 ERE-TATA Binding Protein; HSP27 ERE-TATA-Binding Protein; SAF-B1; SAF-B; SAFB1;
Function
Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816).
Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241).
Thereby acts as a negative regulator of cell proliferation (PubMed:12660241).
When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity).
Biological Process
Biological Process chromatin organizationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process intracellular estrogen receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of mRNA processingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
PTM
Sumoylated by PIAS1 with SUMO1 and SUMO2/3, desumoylated by SENP1. Sumoylation is required for transcriptional repressor activity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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