Mouse Anti-SHPRH Recombinant Antibody (CBXS-5245) (CBMAB-S2460-CQ)

Name: Mouse Anti-SHPRH Recombinant Antibody (CBXS-5245)
SKU: CBMAB-S2460-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBXS-5245

Application

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.3, 1% BSA, 50% glycerol

Preservative

0.02% sodium azide

Concentration

0.88 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

SNF2 Histone Linker PHD RING Helicase

Introduction

SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 (Unk et al., 2006 [PubMed 17108083]).

Entrez Gene ID

257218

UniProt ID

Q149N8

Alternative Names

SNF2 Histone Linker PHD RING Helicase; SNF2, Histone-Linker, PHD And RING Finger Domain-Containing Helicase; SNF2 Histone Linker PHD RING Helicase, E3 Ubiquitin Protein Ligase; RING-Type E3 Ubiquitin Transferase SHPRH; E3 Ubiquitin-Protein Ligase SHPRH; 2610103K11Rik;

Function

E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'.

Biological Process

Biological Process cellular response to DNA damage stimulusManual Assertion Based On ExperimentIDA:MGI
Biological Process DNA repairIEA:UniProtKB-KW
Biological Process nucleosome assemblyIEA:InterPro
Biological Process protein polyubiquitinationManual Assertion Based On ExperimentIDA:FlyBase
Biological Process protein ubiquitinationTAS:Reactome

Cellular Location

nucleoplasm
nucleosome

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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