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SHPRH

SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 (Unk et al., 2006 [PubMed 17108083]).
Full Name
SNF2 Histone Linker PHD RING Helicase
Function
E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'.
Biological Process
Biological Process cellular response to DNA damage stimulusManual Assertion Based On ExperimentIDA:MGI
Biological Process DNA repairIEA:UniProtKB-KW
Biological Process nucleosome assemblyIEA:InterPro
Biological Process protein polyubiquitinationManual Assertion Based On ExperimentIDA:FlyBase
Biological Process protein ubiquitinationTAS:Reactome
Cellular Location
nucleoplasm
nucleosome

Anti-SHPRH antibodies

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Mouse Anti-SHPRH Recombinant Antibody (CBXS-2160) (CBMAB-S4923-CQ)

Datasheet SDS
Target: SHPRH
Host: Mouse
Specificity: Human
Clone: CBXS-2160
Application*: WB, IP, IF, E

Mouse Anti-SHPRH Recombinant Antibody (CBXS-5727) (CBMAB-S0591-CQ)

Datasheet SDS
Target: SHPRH
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5727
Application*: WB

Mouse Anti-SHPRH Recombinant Antibody (CBXS-3967) (CBMAB-S1230-CQ)

Datasheet SDS
Target: SHPRH
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-3967
Application*: WB

Mouse Anti-SHPRH Recombinant Antibody (CBXS-4216) (CBMAB-S1468-CQ)

Datasheet SDS
Target: SHPRH
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-4216
Application*: WB

Mouse Anti-SHPRH Recombinant Antibody (CBXS-4319) (CBMAB-S1564-CQ)

Datasheet SDS
Target: SHPRH
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4319
Application*: DB, IC, WB

Mouse Anti-SHPRH Recombinant Antibody (CBXS-5063) (CBMAB-S2284-CQ)

Datasheet SDS
Target: SHPRH
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5063
Application*: WB

Mouse Anti-SHPRH Recombinant Antibody (CBXS-5160) (CBMAB-S2378-CQ)

Datasheet SDS
Target: SHPRH
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-5160
Application*: WB

Mouse Anti-SHPRH Recombinant Antibody (CBXS-5217) (CBMAB-S2434-CQ)

Datasheet SDS
Target: SHPRH
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-5217
Application*: WB

Mouse Anti-SHPRH Recombinant Antibody (CBXS-5245) (CBMAB-S2460-CQ)

Datasheet SDS
Target: SHPRH
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5245
Application*: WB

Mouse Anti-SHPRH Recombinant Antibody (CBXS-3536) (CBMAB-S6265-CQ)

Datasheet SDS
Target: SHPRH
Host: Mouse
Specificity: Human
Clone: CBXS-3536
Application*: WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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