SHPRH
SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 (Unk et al., 2006 [PubMed 17108083]).
Full Name
SNF2 Histone Linker PHD RING Helicase
Function
E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'.
Biological Process
Biological Process cellular response to DNA damage stimulusManual Assertion Based On ExperimentIDA:MGI
Biological Process DNA repairIEA:UniProtKB-KW
Biological Process nucleosome assemblyIEA:InterPro
Biological Process protein polyubiquitinationManual Assertion Based On ExperimentIDA:FlyBase
Biological Process protein ubiquitinationTAS:Reactome
Biological Process DNA repairIEA:UniProtKB-KW
Biological Process nucleosome assemblyIEA:InterPro
Biological Process protein polyubiquitinationManual Assertion Based On ExperimentIDA:FlyBase
Biological Process protein ubiquitinationTAS:Reactome
Cellular Location
nucleoplasm
nucleosome
nucleosome
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Anti-SHPRH antibodies
+ Filters

Target: SHPRH
Host: Mouse
Specificity: Human
Clone: CBXS-3536
Application*: WB
Target: SHPRH
Host: Mouse
Specificity: Human
Clone: CBXS-2160
Application*: WB, IP, IF, E
Target: SHPRH
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5245
Application*: WB
Target: SHPRH
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-5217
Application*: WB
Target: SHPRH
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-5160
Application*: WB
Target: SHPRH
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5063
Application*: WB
Target: SHPRH
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4319
Application*: DB, IC, WB
Target: SHPRH
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-4216
Application*: WB
Target: SHPRH
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-3967
Application*: WB
Target: SHPRH
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5727
Application*: WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot

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