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Mouse Anti-SHPRH Recombinant Antibody (CBXS-5727) (CBMAB-S0591-CQ)

This product is a mouse antibody that recognizes SHPRH. The antibody CBXS-5727 can be used for immunoassay techniques such as: WB.
See all SHPRH antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-5727
Antibody Isotype
IgG1
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
0.74 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SNF2 Histone Linker PHD RING Helicase
Introduction
SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 (Unk et al., 2006 [PubMed 17108083]).
Entrez Gene ID
257218
UniProt ID
Q149N8
Alternative Names
SNF2 Histone Linker PHD RING Helicase; SNF2, Histone-Linker, PHD And RING Finger Domain-Containing Helicase; SNF2 Histone Linker PHD RING Helicase, E3 Ubiquitin Protein Ligase; RING-Type E3 Ubiquitin Transferase SHPRH; E3 Ubiquitin-Protein Ligase SHPRH; 2610103K11Rik;
Function
E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'.
Biological Process
Biological Process cellular response to DNA damage stimulusManual Assertion Based On ExperimentIDA:MGI
Biological Process DNA repairIEA:UniProtKB-KW
Biological Process nucleosome assemblyIEA:InterPro
Biological Process protein polyubiquitinationManual Assertion Based On ExperimentIDA:FlyBase
Biological Process protein ubiquitinationTAS:Reactome
Cellular Location
nucleoplasm
nucleosome
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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