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Mouse Anti-TAC3 Recombinant Antibody (CBYJT-1766) (CBMAB-T0827-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TAC3 (Tachykinin 3). The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all TAC3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-1766
Antibody Isotype
IgG
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
tachykinin 3
Introduction
TAC3 is a member of the tachykinin family of secreted neuropeptides. The encoded preproprotein is proteolytically processed to generate the mature peptide, which is primarily expressed in the central and peripheral nervous systems and plays a role as a neurotransmitter. TAC3 is the ligand for the neurokinin-3 receptor. TAC3 is also expressed in the outer syncytiotrophoblast of the placenta and may be associated with pregnancy-induced hypertension and pre-eclampsia. Mutations in TAC3 are associated with normosmic hypogonadotropic hypogonadism.
Entrez Gene ID
6866
UniProt ID
Q9UHF0
Alternative Names
NKB; HH10; NKNB; PRO1155; ZNEUROK1
Function
Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles (By similarity).
Is a critical central regulator of gonadal function.
Biological Process
Biological Process female pregnancyTAS:ProtInc1 Publication
Biological Process neuropeptide signaling pathwayIEA:UniProtKB-KW
Biological Process positive regulation of blood pressureIBA:GO_Central1 Publication
Biological Process positive regulation of flagellated sperm motilityIDA:UniProtKB
Biological Process tachykinin receptor signaling pathwayTAS:ProtInc1 Publication
Cellular Location
Secreted
Involvement in disease
Hypogonadotropic hypogonadism 10 with or without anosmia (HH10):
A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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