TAC3

TAC3 is a member of the tachykinin family of secreted neuropeptides. The encoded preproprotein is proteolytically processed to generate the mature peptide, which is primarily expressed in the central and peripheral nervous systems and plays a role as a neurotransmitter. TAC3 is the ligand for the neurokinin-3 receptor. TAC3 is also expressed in the outer syncytiotrophoblast of the placenta and may be associated with pregnancy-induced hypertension and pre-eclampsia. Mutations in TAC3 are associated with normosmic hypogonadotropic hypogonadism.

Full Name

tachykinin 3

Function

Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles (By similarity).
Is a critical central regulator of gonadal function.

Biological Process

Biological Process female pregnancyTAS:ProtInc1 Publication
Biological Process neuropeptide signaling pathwayIEA:UniProtKB-KW
Biological Process positive regulation of blood pressureIBA:GO_Central1 Publication
Biological Process positive regulation of flagellated sperm motilityIDA:UniProtKB
Biological Process tachykinin receptor signaling pathwayTAS:ProtInc1 Publication

Cellular Location

Secreted

Involvement in disease

Hypogonadotropic hypogonadism 10 with or without anosmia (HH10):
A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH).