Mouse Anti-TGIF2 Recombinant Antibody (CBYJT-2845) (CBMAB-T2071-YJ)

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Basic Information

Host Animal
Mouse
Clone
CBYJT-2845
Application
ELISA, WB
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
TGIF2 Gene(Protein Coding) TGFB Induced Factor Homeobox 2
Introduction
TGIF2 is a DNA-binding homeobox protein and a transcriptional repressor, which appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. TGIF2 is amplified and over-expressed in some ovarian cancers.
Entrez Gene ID
UniProt ID
Alternative Names
TGFB Induced Factor Homeobox 2; TGFB-Induced Factor 2 (TALE Family Homeobox); TGF-Beta-Induced Transcription Factor 2; TGFB-Induced Factor Homeobox 2; 5-TG-3-Interacting Factor 2; TGFB-Induced Factor 2
Function
Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins.
Biological Process
Biological Process amacrine cell differentiationSource:Ensembl
Biological Process negative regulation of transcription by RNA polymerase IISource:BHF-UCL1 Publication
Biological Process nodal signaling pathwaySource:Ensembl
Biological Process positive regulation of amacrine cell differentiationSource:Ensembl
Biological Process regulation of DNA-templated transcriptionSource:UniProtKB1 Publication
Biological Process regulation of gastrulationSource:Ensembl
Biological Process regulation of transcription by RNA polymerase IISource:GO_Central1 Publication
Cellular Location
Nucleus
Excluded from nucleoli.
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For research use only. Not intended for any clinical use.

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