TGIF2

The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor, which appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and over-expressed in some ovarian cancers. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. Read-through transcription also exists between this gene and the neighboring downstream C20orf24 (chromosome 20 open reading frame 24) gene. [provided by RefSeq, Dec 2010]

TGIF2 Gene(Protein Coding) TGFB Induced Factor Homeobox 2

Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins.

Biological Process amacrine cell differentiationSource:Ensembl
Biological Process negative regulation of transcription by RNA polymerase IISource:BHF-UCL1 Publication
Biological Process nodal signaling pathwaySource:Ensembl
Biological Process positive regulation of amacrine cell differentiationSource:Ensembl
Biological Process regulation of DNA-templated transcriptionSource:UniProtKB1 Publication
Biological Process regulation of gastrulationSource:Ensembl
Biological Process regulation of transcription by RNA polymerase IISource:GO_Central1 Publication

Nucleus
Excluded from nucleoli.