TGIF2
The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor, which appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and over-expressed in some ovarian cancers. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. Read-through transcription also exists between this gene and the neighboring downstream C20orf24 (chromosome 20 open reading frame 24) gene. [provided by RefSeq, Dec 2010]
Full Name
TGIF2 Gene(Protein Coding) TGFB Induced Factor Homeobox 2
Function
Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins.
Biological Process
Biological Process amacrine cell differentiationSource:Ensembl
Biological Process negative regulation of transcription by RNA polymerase IISource:BHF-UCL1 Publication
Biological Process nodal signaling pathwaySource:Ensembl
Biological Process positive regulation of amacrine cell differentiationSource:Ensembl
Biological Process regulation of DNA-templated transcriptionSource:UniProtKB1 Publication
Biological Process regulation of gastrulationSource:Ensembl
Biological Process regulation of transcription by RNA polymerase IISource:GO_Central1 Publication
Biological Process negative regulation of transcription by RNA polymerase IISource:BHF-UCL1 Publication
Biological Process nodal signaling pathwaySource:Ensembl
Biological Process positive regulation of amacrine cell differentiationSource:Ensembl
Biological Process regulation of DNA-templated transcriptionSource:UniProtKB1 Publication
Biological Process regulation of gastrulationSource:Ensembl
Biological Process regulation of transcription by RNA polymerase IISource:GO_Central1 Publication
Cellular Location
Nucleus
Excluded from nucleoli.
Excluded from nucleoli.
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Anti-TGIF2 antibodies
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CompareTarget: TGIF2
Specificity: Human
Target: TGIF2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-2848
Application*: WB, IP, IF, E
Target: TGIF2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-2847
Application*: WB, IC, IF
Target: TGIF2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-2846
Application*: E, WB
Target: TGIF2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-2845
Application*: E, WB
Target: TGIF2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYJT-2844
Application*: E, WB
Target: TGIF2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-2843
Application*: E, WB
Target: TGIF2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-2842
Application*: E, WB
Target: TGIF2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYJT-2841
Application*: E, WB
Target: TGIF2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYJT-2840
Application*: E, WB
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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