Human Recombinant ING2 protein, GST Tag (V2LY-0526-LY4996)

Name: Human Recombinant ING2 protein, GST Tag
SKU: V2LY-0526-LY4996
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant ING2 protein, GST Tag consist of Amino Acid: Full Length and predicts a molecular mass of 62 kDa.

Molecule Mass

62 kDa

Sequence

Amino Acid: Full Length

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

inhibitor of growth family, member 2

Function

Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs).

Biological Process

Chromatin organizationIEA:UniProtKB-KW
Flagellated sperm motilityBy SimilarityISS:BHF-UCL
Male germ-line stem cell asymmetric divisionBy SimilarityISS:BHF-UCL
Male meiosis IBy SimilarityISS:BHF-UCL
Negative regulation of cell population proliferationIEA:InterPro
Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorManual Assertion Based On ExperimentTAS:BHF-UCL
Positive regulation of histone deacetylationBy SimilarityISS:BHF-UCL
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transforming growth factor beta receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of cellular senescence1 PublicationNAS:BHF-UCL
Regulation of growthIEA:UniProtKB-KW
Regulation of response to DNA damage stimulus1 PublicationNAS:BHF-UCL
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Seminiferous tubule developmentBy SimilarityISS:BHF-UCL
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Spermatid developmentBy SimilarityISS:BHF-UCL
SpermatogenesisBy SimilarityISS:BHF-UCL

Cellular Location

Nucleus. Predominantly nuclear. Localized to chromatin and nuclear matrix. Upon reduced PtdIns(5)P levels seems to be released from chromatin and, at least partially, translocated to the cytoplasm.

PTM

Sumoylation enhances its association with SIN3A and is required for binding to some target gene promoters, this is the case for TMEM71.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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