Human Recombinant NPY protein, hFc Tag (V2LY-0526-LY5768)

Name: Human Recombinant NPY protein, hFc Tag
SKU: V2LY-0526-LY5768
Rating: 5 (1 reviews)

See all NPY antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

hFc Tag

Protein Construction

This product is Human Recombinant NPY protein, hFc Tag consist of Amino Acid: 29-64 and predicts a molecular mass of 32.7 kDa.

Molecule Mass

32.7 kDa

Sequence

Amino Acid: 29-64

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by SDS-PAGE.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Tris, NaCl, Glutathione, EDTA, DTT, PMSF, Glycerol

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Neuropeptide Y

Function

NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.

Biological Process

Adult feeding behaviorISS:HGNC-UCL
AgingIEA:Ensembl
Antibacterial humoral responseIDA:UniProtKB
Antifungal humoral responseIDA:UniProtKB
Antimicrobial humoral immune response mediated by antimicrobial peptideIDA:UniProtKB
Central nervous system neuron developmentManual Assertion Based On ExperimentIEP:DFLAT
Cerebral cortex developmentManual Assertion Based On ExperimentIEP:DFLAT
Chemical synaptic transmissionManual Assertion Based On ExperimentTAS:ProtInc
Defense response to Gram-negative bacteriumIDA:UniProtKB
Defense response to Gram-positive bacteriumIDA:UniProtKB
Feeding behaviorManual Assertion Based On ExperimentIBA:GO_Central
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerManual Assertion Based On ExperimentTAS:ProtInc
Innate immune responseIDA:UniProtKB
Intestinal epithelial cell differentiationManual Assertion Based On ExperimentTAS:GO_Central
Monocyte activationIEA:Ensembl
Negative regulation of acute inflammatory response to antigenic stimulusIEA:Ensembl
Negative regulation of blood pressureIEA:Ensembl
Negative regulation of neuron deathIEA:Ensembl
Neuron projection developmentManual Assertion Based On ExperimentIEP:DFLAT
Neuropeptide signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of appetiteISS:HGNC-UCL
Positive regulation of cell population proliferationIEA:Ensembl
Positive regulation of cell-substrate adhesionIEA:Ensembl
Positive regulation of dopamine metabolic processIEA:Ensembl
Positive regulation of eating behaviorIEA:Ensembl
Positive regulation of ERK1 and ERK2 cascadeIEA:Ensembl
Positive regulation of nitric oxide metabolic processIEA:Ensembl
Regulation of nerve growth factor productionIEA:Ensembl
Response to yeastIDA:UniProtKB
Sensory perception of tasteIEA:Ensembl
Short-day photoperiodismIEA:Ensembl

Cellular Location

Secreted
Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle

PTM

The neuropeptide Y form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro).

McDowell, K., Adamson, C., Jackson, C., Campbell, R., Welsh, P., Petrie, M. C., ... & Herring, N. (2024). Neuropeptide Y is elevated in heart failure and is an independent predictor of outcomes. European Journal of Heart Failure, 26(1), 107-116.

Bale, R., & Doshi, G. (2023). Cross talk about the role of Neuropeptide Y in CNS disorders and diseases. Neuropeptides, 102388.

Park, C., Kim, J., Ko, S. B., Choi, Y. K., Jeong, H., Woo, H., ... & Choi, H. J. (2022). Structural basis of neuropeptide Y signaling through Y1 receptor. Nature communications, 13(1), 853.

Zhang, Y., Liu, C. Y., Chen, W. C., Shi, Y. C., Wang, C. M., Lin, S., & He, H. F. (2021). Regulation of neuropeptide Y in body microenvironments and its potential application in therapies: A review. Cell & Bioscience, 11, 1-14.

Tanaka, M., Yamada, S., & Watanabe, Y. (2021). The role of neuropeptide Y in the nucleus accumbens. International Journal of Molecular Sciences, 22(14), 7287.

Assan, D., Mustapha, U. F., Chen, H., Li, Z., Peng, Y., & Li, G. (2021). The roles of neuropeptide Y (Npy) and peptide YY (Pyy) in teleost food intake: a mini review. Life, 11(6), 547.

Chen, W. C., Liu, Y. B., Liu, W. F., Zhou, Y. Y., He, H. F., & Lin, S. (2020). Neuropeptide Y is an immunomodulatory factor: direct and indirect. Frontiers in immunology, 11, 580378.

Shende, P., & Desai, D. (2020). Physiological and therapeutic roles of neuropeptide Y on biological functions. Cell Biology and Translational Medicine, Volume 7: Stem Cells and Therapy: Emerging Approaches, 37-47.

Corder, K. M., Li, Q., Cortes, M. A., Bartley, A. F., Davis, T. R., & Dobrunz, L. E. (2020). Overexpression of neuropeptide Y decreases responsiveness to neuropeptide Y. Neuropeptides, 79, 101979.

Li, C., Wu, X., Liu, S., Zhao, Y., Zhu, J., & Liu, K. (2019). Roles of neuropeptide Y in neurodegenerative and neuroimmune diseases. Frontiers in Neuroscience, 13, 869.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Human Recombinant NPY protein, hFc Tag?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Rabbit Anti-NPY Recombinant Antibody (CBWJN-0181) (CAT#: CBMAB-N3278-WJ)

Mouse Anti-NPY Recombinant Antibody (CBWJN-0116) (CAT#: CBMAB-N3277-WJ)

Mouse Anti-NPY Recombinant Antibody (8F8) (CAT#: CBMAB-N3284-WJ)

Mouse Anti-NPY Recombinant Antibody (CBWJN-0638) (CAT#: CBMAB-N3288-WJ)

Mouse Anti-NPY Recombinant Antibody (NA) (CAT#: CBMAB-AO809LY)

Mouse Anti-NPY Recombinant Antibody (3B5) (CAT#: CBMAB-N3280-WJ)

Rabbit Anti-NPY Recombinant Antibody (D7Y5A) (CAT#: CBMAB-N3286-WJ)

Mouse Anti-NPY Recombinant Antibody (GF1) (CAT#: CBMAB-N3287-WJ)

Mouse Anti-NPY Recombinant Antibody (CBWJN-1523) (CAT#: CBMAB-N3276-WJ)

Mouse Anti-NPY Recombinant Antibody (CBWJN-0513) (CAT#: CBMAB-N3285-WJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry