Mouse Recombinant IL11 protein (V2LY-0526-LY8462)

Name: Mouse Recombinant IL11 protein
SKU: V2LY-0526-LY8462
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

E. coli

Protein Species

Mouse

Protein Construction

This product is Mouse Recombinant IL11 protein consist of Amino Acid: 22-199 and predicts a molecular mass of 19.2 kDa.

Molecule Mass

19.2 kDa

Sequence

Amino Acid: 22-199

Species

Mouse

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥90% as determined by SDS-PAGE.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Interleukin 11

Function

Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578).

Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and IL11RA activates a signaling cascade that promotes cell proliferation (PubMed:12919066).

Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling' (PubMed:30279168).

Biological Process

B cell differentiation Source: UniProtKB
Fat cell differentiation Source: UniProtKB
Megakaryocyte differentiation Source: UniProtKB
Negative regulation of hormone secretion Source: MGI
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of MAPK cascade Source: MGI
Positive regulation of peptidyl-serine phosphorylation Source: MGI
Positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
Positive regulation of transcription by RNA polymerase II Source: MGI

Cellular Location

Secreted

Involvement in disease

Available under the name Neumega (Wyeth). Used for the prevention of severe thrombocytopenia and the reduction of the need for platelet transfusion following myelosuppressive chemotherapy.

Bai, X., Zhao, G., Chen, Q., Li, Z., Gao, M., Ho, W., ... & Zhang, X. Q. (2022). Inhaled siRNA nanoparticles targeting IL11 inhibit lung fibrosis and improve pulmonary function post-bleomycin challenge. Science Advances, 8(25), eabn7162.

Lim, W. W., Dong, J., Ng, B., Widjaja, A. A., Xie, C., Su, L., ... & Cook, S. A. (2022). Inhibition of IL11 signaling reduces aortic pathology in murine marfan syndrome. Circulation Research, 130(5), 728-740.

Widjaja, A. A., Chothani, S., Viswanathan, S., Goh, J. W. T., Lim, W. W., & Cook, S. A. (2022). IL11 stimulates IL33 expression and proinflammatory fibroblast activation across tissues. International Journal of Molecular Sciences, 23(16), 8900.

Widjaja, A. A., Viswanathan, S., Ting, J. G. W., Tan, J., Shekeran, S. G., Carling, D., ... & Cook, S. A. (2022). IL11 stimulates ERK/P90RSK to inhibit LKB1/AMPK and activate mTOR initiating a mesenchymal program in stromal, epithelial, and cancer cells. Iscience, 25(8).

Dong, J., Viswanathan, S., Adami, E., Singh, B. K., Chothani, S. P., Ng, B., ... & Widjaja, A. A. (2021). Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH. Nature communications, 12(1), 66.

Widjaja, A. A., Dong, J., Adami, E., Viswanathan, S., Ng, B., Pakkiri, L. S., ... & Cook, S. A. (2021). Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury. Science Translational Medicine, 13(597), eaba8146.

Moon, E. J., Mello, S. S., Li, C. G., Chi, J. T., Thakkar, K., Kirkland, J. G., ... & Giaccia, A. J. (2021). The HIF target MAFF promotes tumor invasion and metastasis through IL11 and STAT3 signaling. Nature communications, 12(1), 4308.

Widjaja, A. A., Viswanathan, S., Jinrui, D., Singh, B. K., Tan, J., Wei Ting, J. G., ... & Cook, S. A. (2021). Molecular dissection of pro-fibrotic IL11 signaling in cardiac and pulmonary fibroblasts. Frontiers in Molecular Biosciences, 8, 740650.

Adami, E., Viswanathan, S., Widjaja, A. A., Ng, B., Chothani, S., Zhihao, N., ... & Cook, S. A. (2021). IL11 is elevated in systemic sclerosis and IL11-dependent ERK signalling underlies TGFβ-mediated activation of dermal fibroblasts. Rheumatology, 60(12), 5820-5826.

Styrkarsdottir, U., Lund, S. H., Thorleifsson, G., Zink, F., Stefansson, O. A., Sigurdsson, J. K., ... & Stefansson, K. (2018). Meta-analysis of Icelandic and UK data sets identifies missense variants in SMO, IL11, COL11A1 and 13 more new loci associated with osteoarthritis. Nature genetics, 50(12), 1681-1687.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Cynomolgus Recombinant IL11 protein (CAT#: V2LY-0526-LY1545)

Human Recombinant IL11 protein (CAT#: V2LY-0526-LY4720)

Human Recombinant IL11 protein, His Tag (CAT#: V2LY-0526-LY4721)

Mouse Recombinant IL11 protein, His Tag (CAT#: V2LY-0526-LY8463)

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Human Recombinant IL11 protein, His Tag (CAT#: V2LY-0526-LY4721)

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Isotype control

For research use only. Not intended for any clinical use.

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