Rat Recombinant CDH13 protein, hFc Tag (V2LY-0526-LY9407)

Name: Rat Recombinant CDH13 protein, hFc Tag
SKU: V2LY-0526-LY9407
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Rat

Tag

hFc Tag

Protein Construction

This product is Rat Recombinant CDH13 protein, hFc Tag consist of Amino Acid: 1-692 and predicts a molecular mass of 100.5 kDa.

Molecule Mass

100.5 kDa

Sequence

Amino Acid: 1-692

Species

Rat

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>90% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Cadherin 13

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth.

Biological Process

Adherens junction organization Source: Reactome
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: BHF-UCL
Cell-cell adhesion via plasma-membrane adhesion molecules Source: GO_Central
Endothelial cell migration Source: BHF-UCL
Homophilic cell adhesion via plasma membrane adhesion molecules Source: BHF-UCL
Keratinocyte proliferation Source: BHF-UCL
Lamellipodium assembly Source: BHF-UCL
Localization within membrane Source: BHF-UCL
Low-density lipoprotein particle mediated signaling Source: BHF-UCL
Mitotic cell cycle Source: Ensembl
Negative regulation of cell adhesion Source: BHF-UCL
Negative regulation of cell population proliferation Source: BHF-UCL
Positive regulation of calcium-mediated signaling Source: BHF-UCL
Positive regulation of cell-matrix adhesion Source: BHF-UCL
Positive regulation of cell migration Source: BHF-UCL
Positive regulation of endothelial cell proliferation Source: BHF-UCL
Positive regulation of positive chemotaxis Source: BHF-UCL
Positive regulation of smooth muscle cell proliferation Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Rac protein signal transduction Source: BHF-UCL
Regulation of endocytosis Source: BHF-UCL
Regulation of epidermal growth factor receptor signaling pathway Source: BHF-UCL
Rho protein signal transduction Source: BHF-UCL
Sprouting angiogenesis Source: BHF-UCL

Cellular Location

Cell membrane

Mossink, B., Van Rhijn, J. R., Wang, S., Linda, K., Vitale, M. R., Zöller, J. E., ... & Kasri, N. N. (2021). Cadherin-13 is a critical regulator of GABAergic modulation in human stem-cell-derived neuronal networks. Molecular Psychiatry, 1-18.

Shiu, B. H., Lu, W. Y., Tantoh, D. M., Chou, M. C., Nfor, O. N., Huang, C. C., & Liaw, Y. P. (2021). Interactive association between dietary fat and sex on CDH13 cg02263260 methylation. BMC Medical Genomics, 14(1), 1-9.

Xu, D., Yuan, H., Meng, Z., Yang, C., Li, Z., Li, M., ... & Tu, H. (2020). Cadherin 13 inhibits pancreatic cancer progression and epithelial-mesenchymal transition by Wnt/β-catenin signaling. Journal of Cancer, 11(8), 2101.

Yang, Y. R., Kabir, M. H., Park, J. H., Park, J. I., Kang, J. S., Ju, S., ... & Kwon, K. S. (2020). Plasma proteomic profiling of young and old mice reveals cadherin-13 prevents age-related bone loss. Aging (Albany NY), 12(9), 8652.

Forero, A., Ku, H. P., Malpartida, A. B., Wäldchen, S., Alhama-Riba, J., Kulka, C., ... & Lesch, K. P. (2020). Serotonin (5-HT) neuron-specific inactivation of Cadherin-13 impacts 5-HT system formation and cognitive function. Neuropharmacology, 168, 108018.

Kiser, D. P., Popp, S., Schmitt-Boehrer, A. G., Strekalova, T., van den Hove, D. L., Lesch, K. P., & Rivero, O. (2019). Early-life stress impairs developmental programming in Cadherin 13 (CDH13)-deficient mice. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 89, 158-168.

Tantra, M., Guo, L., Kim, J., Zainolabidin, N., Eulenburg, V., Augustine, G. J., & Chen, A. I. (2018). Conditional deletion of Cadherin 13 perturbs Golgi cells and disrupts social and cognitive behaviors. Genes, Brain and Behavior, 17(6), e12466.

Killen, A. C., Barber, M., Paulin, J. J., Ranscht, B., Parnavelas, J. G., & Andrews, W. D. (2017). Protective role of Cadherin 13 in interneuron development. Brain Structure and Function, 222(8), 3567-3585.

Forero, A., Rivero, O., Wäldchen, S., Ku, H. P., Kiser, D. P., Gärtner, Y., ... & Lesch, K. P. (2017). Cadherin-13 deficiency increases dorsal raphe 5-HT neuron density and prefrontal cortex innervation in the mouse brain. Frontiers in cellular neuroscience, 11, 307.

Vargas-Alarcon, G., Martinez-Rodriguez, N., Velazquez-Cruz, R., Perez-Mendez, O., Posadas-Sanchez, R., Posadas-Romero, C., ... & Fragoso, J. M. (2017). The T> A (rs11646213) gene polymorphism of cadherin-13 (CDH13) gene is associated with decreased risk of developing hypertension in Mexican population. Immunobiology, 222(10), 973-978.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Cynomolgus Recombinant CDH13 protein, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY1527)

Mouse Recombinant CDH13 protein, hFc Tag (CAT#: V2LY-0526-LY8381)

Mouse Recombinant CDH13 protein, His Tag (CAT#: V2LY-0526-LY8382)

Rat Recombinant CDH13 protein (CAT#: V2LY-0526-LY9406)

Rat Recombinant CDH13 protein, His Tag (CAT#: V2LY-0526-LY9408)

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Mouse Recombinant CDH13 protein, hFc Tag (CAT#: V2LY-0526-LY8381)

Mouse Recombinant CDH13 protein, His Tag (CAT#: V2LY-0526-LY8382)

Rat Recombinant CDH13 protein, His Tag (CAT#: V2LY-0526-LY9408)

Cynomolgus Recombinant CDH13 protein, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY1527)

Rat Anti-CDH13 Recombinant Antibody (CBFYH-0066) (CAT#: CBMAB-H0888-FY)

Rabbit Anti-CDH13 Recombinant Antibody (EG582) (CAT#: CBMAB-EN703-LY)

Rat Recombinant CDH13 protein (CAT#: V2LY-0526-LY9406)

Mouse Anti-CDH13 Recombinant Antibody (CBFYH-0065) (CAT#: CBMAB-H0887-FY)

Mouse Anti-CDH13 Recombinant Antibody (3H4) (CAT#: CBMAB-C6313-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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