AGPAT2

Agpat2 is a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. The protein is located within the endoplasmic reticulum membrane and converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis.

Full Name

1-Acylglycerol-3-Phosphate O-Acyltransferase 2

Function

Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.

Biological Process

CDP-diacylglycerol biosynthetic process
Epidermis development
Neutrophil degranulation
Phosphatidic acid biosynthetic process
Phospholipid metabolic process
Positive regulation of cytokine-mediated signaling pathway
Positive regulation of cytokine production
Response to drug

Cellular Location

Endoplasmic reticulum membrane

Involvement in disease

Congenital generalized lipodystrophy 1 (CGL1): An autosomal recessive disorder characterized by a near complete absence of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and early onset of diabetes.

Topology

Lumenal: 24-29 aa
Helical: 30-50 aa
Cytoplasmic: 51-121 aa
Helical: 122-142 aa
Lumenal: 143-278 aa