AGPAT2

Agpat2 is a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. The protein is located within the endoplasmic reticulum membrane and converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis.

Full Name

1-Acylglycerol-3-Phosphate O-Acyltransferase 2

Function

Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.

Biological Process

CDP-diacylglycerol biosynthetic process
Epidermis development
Neutrophil degranulation
Phosphatidic acid biosynthetic process
Phospholipid metabolic process
Positive regulation of cytokine-mediated signaling pathway
Positive regulation of cytokine production
Response to drug

Cellular Location

Endoplasmic reticulum membrane

Involvement in disease

Congenital generalized lipodystrophy 1 (CGL1): An autosomal recessive disorder characterized by a near complete absence of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and early onset of diabetes.

Topology

Lumenal: 24-29 aa
Helical: 30-50 aa
Cytoplasmic: 51-121 aa
Helical: 122-142 aa
Lumenal: 143-278 aa

Anti-AGPAT2 antibodies

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Rabbit Anti-AGPAT2 Recombinant Antibody (V2-180182) (CBMAB-A1603-YC)

Datasheet

SDS

Target: AGPAT2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: V2-180182

Application*: WB, IP

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)