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ALDH3A1

Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008]

Full Name

Aldehyde Dehydrogenase 3 Family Member A1

Function

ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (PubMed:1737758). Preferentially oxidizes aromatic aldehyde substrates (PubMed:1737758). Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity).

Biological Process

Aging Source: Ensembl
Cellular aldehyde metabolic process Source: UniProtKB
Positive regulation of cell population proliferation Source: Ensembl
Response to cAMP Source: Ensembl
Response to drug Source: Ensembl
Response to glucocorticoid Source: Ensembl
Response to hypoxia Source: Ensembl
Response to nutrient Source: Ensembl
Xenobiotic metabolic process Source: Reactome

Cellular Location

Cytoplasm

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Anti-ALDH3A1 antibodies

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Mouse Anti-ALDH3A1 Recombinant Antibody (G2) (CBMAB-A2282-YC)

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Target: ALDH3A1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse, Rat

Clone: G2

Application*: E, IC, IF, IH, WB

Mouse Anti-ALDH3A1 Recombinant Antibody (B8) (CBMAB-A2280-YC)

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Target: ALDH3A1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: B8

Application*: E, IC, IF, IH, WB

Dog ALDH3A1 ELISA Kit (V2LY-0626-LY831)

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Target: ALDH3A1

Sensitivity: 0.011 ng/mL

Detection Range: 0.02-3.5 ng/mL

Sample Type: Serum, Plasma, cell culture supernates

Specificity: Dog

Assay Type: Sandwich

Reactivity: Dog

Human Recombinant ALDH3A1 protein, His Tag (V2LY-0526-LY1999)

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Target: ALDH3A1

Expressed Host: Baculovirus-Insect Cells

Sequence: Amino Acid: 1-453

Tag: His Tag

ALDH3A1 Matched Antibody Pair (064) (APMAB-064LY)

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Target: ALDH3A1

Specificity: Human

ALDH3A1 Matched Antibody Pair (063) (APMAB-063LY)

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Target: ALDH3A1

Specificity: Human

Rabbit Anti-ALDH3A1 Recombinant Antibody (BA0332) (CBMAB-0058CQ)

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Target: ALDH3A1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: BA0332

Application*: WB, E

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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