ARL1

ARL1 belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). ARFs, described as activators of cholera toxin (CT) ADP-ribosyltransferase activity, regulate intracellular vesic

Full Name

ADP Ribosylation Factor Like GTPase 1

Function

GTP-binding protein that recruits several effectors, such as golgins, arfaptins and Arf-GEFs to the trans-Golgi network, and modulates their functions at the Golgi complex (PubMed:9624189, PubMed:21239483, PubMed:27436755, PubMed:22679020, PubMed:27373159).
Plays thereby a role in a wide range of fundamental cellular processes, including cell polarity, innate immunity, or protein secretion mediated by arfaptins, which were shown to play a role in maintaining insulin secretion from pancreatic beta cells (PubMed:22981988).

Biological Process

Activation of phospholipase D activity Source: UniProtKB
Golgi organization Source: UniProtKB
Intracellular protein transport Source: GO_Central
Protein localization to Golgi apparatus Source: UniProtKB
Retrograde transport, endosome to Golgi Source: UniProtKB
Toxin metabolic process Source: UniProtKB
Vesicle-mediated transport Source: GO_Central

Cellular Location

Golgi apparatus membrane; Trans-Golgi network membrane; Membrane