ASGR2
This cell surface receptor binds to galactose-terminated glycoproteins. It transports these glycoproteins via a series of membrane vesicles and tubules to an acidic-sorting organelle where the receptor and ligand dissociates. Then the receptor is recycled back to the cell surface. There are four alternatively spliced transcript variants of this gene. [provided by RefSeq]
Full Name
asialoglycoprotein receptor 2
Function
Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.
Biological Process
Bone mineralization Source: Ensembl
Cell surface receptor signaling pathway Source: ProtInc
Lipid homeostasis Source: Ensembl
Protein N-linked glycosylation via asparagine Source: Reactome
Regulation of protein stability Source: Ensembl
Viral process Source: UniProtKB-KW
Cell surface receptor signaling pathway Source: ProtInc
Lipid homeostasis Source: Ensembl
Protein N-linked glycosylation via asparagine Source: Reactome
Regulation of protein stability Source: Ensembl
Viral process Source: UniProtKB-KW
Cellular Location
Membrane
Topology
Cytoplasmic: 1-58 aa
Helical: 59-79 aa
Extracellular: 80-311 aa
Helical: 59-79 aa
Extracellular: 80-311 aa
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Anti-ASGR2 antibodies
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Target: ASGR2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1D7
Application*: WB, E
Target: ASGR2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBCNC-118
Application*: WB, IP, IF, E, P
Target: ASGR2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2389
Application*: IH, F
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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