ASGR2

This cell surface receptor binds to galactose-terminated glycoproteins. It transports these glycoproteins via a series of membrane vesicles and tubules to an acidic-sorting organelle where the receptor and ligand dissociates. Then the receptor is recycled back to the cell surface. There are four alternatively spliced transcript variants of this gene. [provided by RefSeq]

asialoglycoprotein receptor 2

Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.

Bone mineralization Source: Ensembl
Cell surface receptor signaling pathway Source: ProtInc
Lipid homeostasis Source: Ensembl
Protein N-linked glycosylation via asparagine Source: Reactome
Regulation of protein stability Source: Ensembl
Viral process Source: UniProtKB-KW

Membrane

Cytoplasmic: 1-58 aa
Helical: 59-79 aa
Extracellular: 80-311 aa