ASGR2

This cell surface receptor binds to galactose-terminated glycoproteins. It transports these glycoproteins via a series of membrane vesicles and tubules to an acidic-sorting organelle where the receptor and ligand dissociates. Then the receptor is recycled back to the cell surface. There are four alternatively spliced transcript variants of this gene. [provided by RefSeq]
Full Name
asialoglycoprotein receptor 2
Function
Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.
Biological Process
Bone mineralization Source: Ensembl
Cell surface receptor signaling pathway Source: ProtInc
Lipid homeostasis Source: Ensembl
Protein N-linked glycosylation via asparagine Source: Reactome
Regulation of protein stability Source: Ensembl
Viral process Source: UniProtKB-KW
Cellular Location
Membrane
Topology
Cytoplasmic: 1-58 aa
Helical: 59-79 aa
Extracellular: 80-311 aa
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Anti-ASGR2 antibodies

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Mouse Anti-ASGR2 Recombinant Antibody (1D7) (CBMAB-A0538-LY)

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Target: ASGR2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1D7
Application*: WB, E
Datasheet SDS

Mouse Anti-ASGR2 Recombinant Antibody (CBCNC-118) (CBMAB-C1079-CN)

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Target: ASGR2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBCNC-118
Application*: WB, IP, IF, E, P
Datasheet SDS

Mouse Anti-ASGR2 Recombinant Antibody (CBT2389) (V2LY-0625-LY1405)

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Target: ASGR2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2389
Application*: IH, F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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