Mouse Anti-ASGR2 Recombinant Antibody (CBT2389) (V2LY-0625-LY1405)

Name: Mouse Anti-ASGR2 Recombinant Antibody (CBT2389)
SKU: V2LY-0625-LY1405
Rating: 5 (1 reviews)

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Tested Data

Mouse Anti-ASGR2 Recombinant Antibody (CBT2389) (V2LY-0625-LY1405) in ELISA

Mouse Anti-ASGR2 Recombinant Antibody (CBT2389) (V2LY-0625-LY1405) in WB

Mouse Anti-ASGR2 Recombinant Antibody (CBT2389) (V2LY-0625-LY1405) in FC

Mouse Anti-ASGR2 Recombinant Antibody (CBT2389) (V2LY-0625-LY1405) in IHC

Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBT2389

Application

IHC, FC

Immunogen

Purified recombinant fragment of human ASGR2 (AA: 80-311) expressed in E. Coli.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:2,000
IHC-P	1:200-1:1,000
FC	1:200-1:400
ELISA	1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

asialoglycoprotein receptor 2

Entrez Gene ID

433

UniProt ID

P07307

Function

Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.

Biological Process

Bone mineralization Source: Ensembl
Cell surface receptor signaling pathway Source: ProtInc
Lipid homeostasis Source: Ensembl
Protein N-linked glycosylation via asparagine Source: Reactome
Regulation of protein stability Source: Ensembl
Viral process Source: UniProtKB-KW

Cellular Location

Membrane

Topology

Cytoplasmic: 1-58 aa
Helical: 59-79 aa
Extracellular: 80-311 aa

Lunghi, B., Morfini, M., Martinelli, N., Balestra, D., Linari, S., Frusconi, S., ... & Bernardi, F. (2021). The asialoglycoprotein receptor minor subunit gene (ASGR2) contributes to pharmacokinetics of factor VIII concentrates in Hemophilia A. Thrombosis and Haemostasis, (AAM).

Lunghi, B., Morfini, M., Martinelli, N., Frusconi, S., Balestra, D., Branchini, A., ... & Bernardi, F. (2020). The asialoglycoprotein receptor ASGR2 5’UTR polymorphisms influence several parameters of full-length FVIII concentrate pharmacokinetics. In XVII Convegno Triennale sui Problemi Clinici e Sociali dell’Emofilia e delle Malattie Emorragiche Congenite (Vol. 18, No. Supplement 3, pp. 350-351). SIMTI.

Lunghi, B., Morfini, M., Martinelli, N., Frusconi, S., Balestra, D., Branchini, A., ... & Bernardi, F. (2020). Contribution of asialoglycoprotein receptor ASGR2 5’UTR polymorphisms to full-length FVIII concentrate pharmacokinetics. In XXVI Congresso Nazionale della Società Italiana per lo Studio dell'Emostasi e della Trombosi-SISET (Vol. 18, No. Supplement 4, pp. 431-432). SIMTI.

Tanaka, H., Kanda, M., Miwa, T., Tanaka, C., Kobayashi, D., Umeda, S., ... & Kodera, Y. (2018). Pattern-specific transcriptomics identifies ASGR2 as a predictor of hematogenous recurrence of gastric cancer. Molecular Cancer Research, 16(9), 1420-1429.

Tanaka, H. (2017). Roles of asialoglycoprotein receptor 2 in gastric cancer progression.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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