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Mouse Anti-ASGR2 Recombinant Antibody (CBCNC-118) (CBMAB-C1079-CN)

This product is a Mouse antibody that recognizes ASGR2. The antibody CBCNC-118 can be used for immunoassay techniques such as: WB, ICC, IHC-P, IHC-F, ELISA.
See all ASGR2 antibodies
Published Data
Mouse Anti-ASGR2 Recombinant Antibody (CBCNC-118) CBMAB-C1079-CN in WB
ASGPR protein levels of HepaRG overexpressing ASGPR-1/-2 was assessed by western blotting and compared to differentiated (dHepaRG) and undifferentiated HepaRG (HepaRG). Anti-actin Ab was used as loading control. ...View More
Javanbakht, H., Mueller, H., Walther, J., Zhou, X., Lopez, A., Pattupara, T., ... & Ottosen, S. (2018). Liver-targeted anti-HBV single-stranded oligonucleotides with locked nucleic acid potently reduce HBV gene expression in vivo. Molecular Therapy-Nucleic Acids, 11, 441-454.

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBCNC-118
Antibody Isotype
IgG1, κ
Application
WB, IP, IF, ELISA, IHC-P

Basic Information

Immunogen
Amino acids 81-135 mapping within an internal region of ASGPR2 of human origin.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000
IHC-P1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml

Target

Full Name
asialoglycoprotein receptor 2
Introduction
This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Entrez Gene ID
433
UniProt ID
P07307
Alternative Names
Asialoglycoprotein Receptor 2; C-Type Lectin Domain Family 4 Member H2; Hepatic Lectin H2; CLEC4H2; HL-2; HBxAg-Binding Protein;
Function
Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.
Biological Process
Bone mineralization Source: Ensembl
Cell surface receptor signaling pathway Source: ProtInc
Lipid homeostasis Source: Ensembl
Protein N-linked glycosylation via asparagine Source: Reactome
Regulation of protein stability Source: Ensembl
Viral process Source: UniProtKB-KW
Cellular Location
Membrane
Topology
Cytoplasmic: 1-58 aa
Helical: 59-79 aa
Extracellular: 80-311 aa
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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