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CCNH

CCNH (Cyclin H) is a Protein Coding gene. Diseases associated with CCNH include Breast Cancer and Fructose Intolerance, Hereditary. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance and Formation of HIV elongation complex in the absence of HIV Tat. Gene Ontology (GO) annotations related to this gene include protein kinase binding and DNA-dependent ATPase activity.
Full Name
Cyclin H
Function
Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.
Biological Process
7-methylguanosine mRNA capping Source: Reactome
G1/S transition of mitotic cell cycle Source: Reactome
G2/M transition of mitotic cell cycle Source: Reactome
Nucleotide-excision repair, preincision complex assembly Source: Reactome
Phosphorylation of RNA polymerase II C-terminal domain Source: GO_Central
Protein stabilization Source: CAFA
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
Regulation of transcription by RNA polymerase II Source: GO_Central
Termination of RNA polymerase I transcription Source: Reactome
Transcription by RNA polymerase II Source: UniProtKB
Transcription-coupled nucleotide-excision repair Source: Reactome
Transcription elongation from RNA polymerase II promoter Source: Reactome
Transcription initiation from RNA polymerase II promoter Source: ARUK-UCL
Transcription initiation from RNA polymerase I promoter Source: Reactome
Cellular Location
Nucleus
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Anti-CCNH antibodies

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Mouse Anti-CCNH Recombinant Antibody (CBFYC-1054) (CBMAB-C1111-FY)

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Target: CCNH
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: CBFYC-1054
Application*: WB, IP, IF, E, P
Datasheet SDS

Rabbit Anti-CCNH Recombinant Antibody (CBFYC-1057) (CBMAB-C1114-FY)

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Target: CCNH
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBFYC-1057
Application*: F, IF, IP, WB, IH
Datasheet SDS

Rabbit Anti-CCNH Recombinant Antibody (CBFYC-1056) (CBMAB-C1113-FY)

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Target: CCNH
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBFYC-1056
Application*: E, IF, P, WB
Datasheet SDS

Mouse Anti-CCNH Recombinant Antibody (CBFYC-1055) (CBMAB-C1112-FY)

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Target: CCNH
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYC-1055
Application*: IP, WB
Datasheet SDS

Mouse Anti-CCNH Recombinant Antibody (4E11-G2-D7) (CBMAB-C6843-LY)

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Target: CCNH
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 4E11-G2-D7
Application*: IP, WB
Datasheet SDS

Mouse Anti-CCNH Recombinant Antibody (3G6) (CBMAB-C1134-LY)

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Target: CCNH
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: 3G6
Application*: WB
Datasheet SDS

Mouse Anti-CCNH Recombinant Antibody (CBT398) (V2LY-0625-LY3554)

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Target: CCNH
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Dog, Pig
Clone: CBT398
Application*: WB
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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