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CCNH

CCNH (Cyclin H) is a Protein Coding gene. Diseases associated with CCNH include Breast Cancer and Fructose Intolerance, Hereditary. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance and Formation of HIV elongation complex in the absence of HIV Tat. Gene Ontology (GO) annotations related to this gene include protein kinase binding and DNA-dependent ATPase activity.

Full Name

Cyclin H

Function

Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

Biological Process

7-methylguanosine mRNA capping Source: Reactome
G1/S transition of mitotic cell cycle Source: Reactome
G2/M transition of mitotic cell cycle Source: Reactome
Nucleotide-excision repair, preincision complex assembly Source: Reactome
Phosphorylation of RNA polymerase II C-terminal domain Source: GO_Central
Protein stabilization Source: CAFA
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
Regulation of transcription by RNA polymerase II Source: GO_Central
Termination of RNA polymerase I transcription Source: Reactome
Transcription by RNA polymerase II Source: UniProtKB
Transcription-coupled nucleotide-excision repair Source: Reactome
Transcription elongation from RNA polymerase II promoter Source: Reactome
Transcription initiation from RNA polymerase II promoter Source: ARUK-UCL
Transcription initiation from RNA polymerase I promoter Source: Reactome

Cellular Location

Nucleus

Anti-CCNH antibodies

Mouse Anti-CCNH Recombinant Antibody (CBFYC-1057) (CBMAB-C1114-FY)

SDS

Target: CCNH

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBFYC-1057

Application*: DB

Mouse Anti-CCNH (AA 1-110) Recombinant Antibody (CBFYC-1056) (CBMAB-C1113-FY)

SDS

Target: CCNH

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBFYC-1056

Application*: E, IF, P, WB

Mouse Anti-CCNH Recombinant Antibody (CBFYC-1055) (CBMAB-C1112-FY)

SDS

Target: CCNH

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYC-1055

Application*: E, WB

Mouse Anti-CCNH (N-terminus) Recombinant Antibody (CBFYC-1054) (CBMAB-C1111-FY)

SDS

Target: CCNH

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBFYC-1054

Application*: IP, WB

Mouse Anti-CCNH Recombinant Antibody (EG519) (CBMAB-EN592-LY)

SDS

Target: CCNH

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: EG519

Application*: WB, IP

Mouse Anti-CCNH Recombinant Antibody (CAP371) (CBMAB-AP912LY)

SDS

Target: CCNH

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CAP371

Application*: IP, WB

Mouse Anti-CCNH Recombinant Antibody (CAP370) (CBMAB-AP911LY)

SDS

Target: CCNH

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse, Pig, Rat

Clone: CAP370

Application*: ELISA, WB

Mouse Anti-CCNH Recombinant Antibody (CAP369) (CBMAB-AP910LY)

SDS

Target: CCNH

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Rat, Dog, Mouse, Pig

Clone: CAP369

Application*: ELISA, WB

Mouse Anti-CCNH Recombinant Antibody (CB443A) (CBMAB-CA443LY)

SDS

Target: CCNH

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Rat, Dog, Mouse, Pig

Clone: CB443A

Application*: ELISA, WB

Mouse Anti-CCNH Recombinant Antibody (1A7-B5-D4) (CBMAB-Z0518-LY)

SDS

Target: CCNH

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Mouse

Clone: 1A7-B5-D4

Application*: WB

Mouse Anti-CCNH Recombinant Antibody (Mo-1.1) (CBMAB-C9912-LY)

SDS

Target: CCNH

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: Mo-1.1

Application*: F

Mouse Anti-CCNH Recombinant Antibody (8J106) (CBMAB-C1475-CN)

SDS

Target: CCNH

Host: Mouse

Specificity: Human

Clone: 8J106

Application*: DB, WB

Mouse Anti-CCNH Recombinant Antibody (15B137) (CBMAB-C0081-CN)

SDS

Target: CCNH

Host: Mouse

Specificity: Human

Clone: 15B137

Application*: IP, WB

Recombinant Mouse Anti-CCNH Recombinant Antibody (2D4) (CBMAB-XB0137-YC)

SDS

Target: CCNH

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 2D4

Application*: E, IF, WB

Mouse Anti-CCNH Recombinant Antibody (CBYY-C0082) (CBMAB-C0406-YY)

SDS

Target: CCNH

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBYY-C0082

Application*: WB, F, E, IF

Mouse Anti-CCNH Recombinant Antibody (4E11-G2-D7) (CBMAB-C6843-LY)

SDS

Target: CCNH

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 4E11-G2-D7

Application*: WB

Mouse Anti-CCNH Recombinant Antibody (33TF2-2D4) (CBMAB-C5536-LY)

SDS

Target: CCNH

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 33TF2-2D4

Application*: IC, IF, IP, WB

Mouse Anti-CCNH Recombinant Antibody (2A18) (CBMAB-C4591-LY)

SDS

Target: CCNH

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2A18

Application*: E, WB

Mouse Anti-CCNH Recombinant Antibody (1B8) (CBMAB-C3675-LY)

SDS

Target: CCNH

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 1B8

Application*: E, IC/IF, P, WB

Mouse Anti-CCNH Recombinant Antibody (13k39) (CBMAB-C2948-LY)

SDS

Target: CCNH

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 13k39

Application*: IP, WB

Mouse Anti-CCNH Recombinant Antibody (3G6) (CBMAB-C1134-LY)

SDS

Target: CCNH

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 3G6

Application*: WB, F, E, IC/IF

Mouse Anti-CCNH Recombinant Antibody (2125C2a) (CBMAB-C0609-LY)

SDS

Target: CCNH

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 2125C2a

Application*: DB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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