CCR1

CCR1 (C-C Motif Chemokine Receptor 1) is a Protein Coding gene. Diseases associated with CCR1 include Immune-Complex Glomerulonephritis and Chromoblastomycosis. Among its related pathways are Cytokine Signaling in Immune system and Akt Signaling. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and chemokine receptor activity. An important paralog of this gene is CCR3.

Full Name

C-C Motif Chemokine Receptor 1

Function

Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation.

Biological Process

Calcium ion transport Source: UniProtKB
Calcium-mediated signaling Source: GO_Central
Cell adhesion Source: ProtInc
Cell-cell signaling Source: UniProtKB
Cell chemotaxis Source: GO_Central
Cell surface receptor signaling pathway Source: ProtInc
Cellular calcium ion homeostasis Source: UniProtKB
Chemokine-mediated signaling pathway Source: UniProtKB
Chemotaxis Source: UniProtKB
Cytokine-mediated signaling pathway Source: Reactome
Dendritic cell chemotaxis Source: BHF-UCL
Exocytosis Source: UniProtKB
G protein-coupled receptor signaling pathway Source: Reactome
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
Immune response Source: UniProtKB
Inflammatory response Source: GO_Central
Negative regulation of bone mineralization Source: UniProtKB
Negative regulation of gene expression Source: UniProtKB
Positive regulation of calcium ion transport Source: UniProtKB
Positive regulation of cell migration Source: CACAO
Positive regulation of cytosolic calcium ion concentration Source: UniProtKB
Positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
Positive regulation of monocyte chemotaxis Source: UniProtKB
Positive regulation of osteoclast differentiation Source: UniProtKB
Response to wounding Source: ProtInc

Cellular Location

Cell membrane

Topology

Extracellular: 1-34
Helical: 35-60
Cytoplasmic: 61-64
Helical: 65-91
Extracellular: 92-107
Helical: 108-129
Cytoplasmic: 130-146
Helical: 147-171
Extracellular: 172-197
Helical: 198-223
Cytoplasmic: 224-239
Helical: 240-264
Extracellular: 265-281
Helical: 282-305
Cytoplasmic: 306-355