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CDX2

This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis. [provided by RefSeq, Jan 2012]
Full Name
Caudal Type Homeobox 2
Function
Transcription factor which regulates the transcription of multiple genes expressed in the intestinal epithelium (By similarity).
Binds to the promoter of the intestinal sucrase-isomaltase SI and activates SI transcription (By similarity).
Binds to the DNA sequence 5'-ATAAAAACTTAT-3' in the promoter region of VDR and activates VDR transcription (By similarity).
Binds to and activates transcription of LPH (By similarity).
Activates transcription of CLDN2 and intestinal mucin MUC2 (By similarity).
Binds to the 5'-AATTTTTTACAACACCT-3' DNA sequence in the promoter region of CA1 and activates CA1 transcription (By similarity).
Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Binds preferentially to methylated DNA (PubMed:28473536).
Biological Process
Animal organ morphogenesis Source: GO_Central
Anterior/posterior axis specification Source: GO_Central
Blood vessel development Source: Ensembl
Cell differentiation Source: GO_Central
Endosome to lysosome transport Source: Ensembl
Establishment or maintenance of epithelial cell apical/basal polarity Source: Ensembl
Intestinal epithelial cell differentiation Source: UniProtKB
Labyrinthine layer development Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: NTNU_SB
Positive regulation of cell differentiation Source: Ensembl
Positive regulation of cell population proliferation Source: Ensembl
Positive regulation of transcription, DNA-templated Source: Ensembl
Regulation of somitogenesis Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Somatic stem cell population maintenance Source: Ensembl
Trophectodermal cell differentiation Source: Ensembl
Cellular Location
Nucleus
PTM
Ubiquitinated, leading to its degradation by the proteasome.
Phosphorylation at Ser-60 reduces transactivation capacity. Phosphorylation at Ser-283 reduces transactivation capacity and also increases ubiquitin-dependent proteasome degradation.

Anti-CDX2 antibodies

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Mouse Anti-CDX2 Recombinant Antibody (CBXC-1898) (CBMAB-C5650-CQ)

Datasheet SDS
Target: CDX2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Dog
Clone: CBXC-1898
Application*: WB

Mouse Anti-CDX2 Recombinant Antibody (AMT28) (CBMAB-C5649-CQ)

Datasheet SDS
Target: CDX2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: AMT28
Application*: IH, P

Rabbit Anti-CDX2 Recombinant Antibody (CBXC-2660) (CBMAB-C5648-CQ)

Datasheet SDS
Target: CDX2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXC-2660
Application*: IH

Rabbit Anti-CDX2 Recombinant Antibody (SP54) (CBMAB-C5647-CQ)

Datasheet SDS
Target: CDX2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: SP54
Application*: F, IH, P

Mouse Anti-CDX2 Recombinant Antibody (CBXC-2870) (CBMAB-C5646-CQ)

Datasheet SDS
Target: CDX2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2870
Application*: WB, F, E, MC

Mouse Anti-CDX2 Recombinant Antibody (CBXC-2749) (CBMAB-C5645-CQ)

Datasheet SDS
Target: CDX2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2749
Application*: WB, E

Mouse Anti-CDX2 Recombinant Antibody (CBXC-0352) (CBMAB-C5644-CQ)

Datasheet SDS
Target: CDX2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXC-0352
Application*: E, P, WB

Mouse Anti-CDX2 Recombinant Antibody (CBXC-2202) (CBMAB-C5641-CQ)

Datasheet SDS
Target: CDX2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXC-2202
Application*: WB

Mouse Anti-CDX2 Recombinant Antibody (CBXC-2123) (CBMAB-C5640-CQ)

Datasheet SDS
Target: CDX2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2123
Application*: WB, IH

Mouse Anti-CDX2 Recombinant Antibody (CBXC-2607) (CBMAB-C5639-CQ)

Datasheet SDS
Target: CDX2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBXC-2607
Application*: E, WB

Mouse Anti-CDX2 Recombinant Antibody (CDX2/1690) (CBMAB-C0544-CQ)

Datasheet SDS
Target: CDX2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CDX2/1690
Application*: F, E, IF, P

Mouse Anti-CDX2 Recombinant Antibody (CBFYC-1664) (CBMAB-C1726-FY)

Datasheet SDS
Target: CDX2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: CBFYC-1664
Application*: IC, IP, WB

Mouse Anti-CDX2 Recombinant Antibody (CBFYC-1663) (CBMAB-C1725-FY)

Datasheet SDS
Target: CDX2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBFYC-1663
Application*: WB, IH

Mouse Anti-CDX2 (AA 1-314) Recombinant Antibody (CBFYC-1662) (CBMAB-C1724-FY)

Datasheet SDS
Target: CDX2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYC-1662
Application*: E, P, WB

Mouse Anti-CDX2 Recombinant Antibody (CBFYC-1661) (CBMAB-C1723-FY)

Datasheet SDS
Target: CDX2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYC-1661
Application*: WB

Mouse Anti-CDX2 Antibody (1A6) (CBMAB-0213-YC)

Datasheet SDS
Target: CDX2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1A6
Application*: WB, M

Mouse Anti-CDX2 Antibody (1A3) (CBMAB-0212-YC)

Datasheet SDS
Target: CDX2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1A3
Application*: WB, M

Rabbit Anti-CDX2 Monoclonal Antibody (EPR2764Y) (CBMAB-R0018-FY)

Datasheet SDS
Target: CDX2
Host: Rabbit
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: EPR2764Y
Application*: ELISA

Mouse Anti-CDX2 Recombinant Antibody (913) (CBMAB-AP1430LY)

Datasheet SDS
Target: CDX2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 913
Application*: ELISA, WB

Mouse Anti-CDX2 Recombinant Antibody (CAP478) (CBMAB-AP1428LY)

Datasheet SDS
Target: CDX2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CAP478
Application*: IF, IP, WB

Mouse Anti-CDX2 Recombinant Antibody (CAP477) (CBMAB-AP1427LY)

Datasheet SDS
Target: CDX2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Monkey, Mouse
Clone: CAP477
Application*: ICC, IP, WB

Mouse Anti-CDX2 Recombinant Antibody (CAP476) (CBMAB-AP1426LY)

Datasheet SDS
Target: CDX2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CAP476
Application*: IHC, WB

Mouse Anti-CDX2 Recombinant Antibody (CAP475) (CBMAB-AP1425LY)

Datasheet SDS
Target: CDX2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Monkey, Mouse
Clone: CAP475
Application*: ICC, IP, WB

Mouse Anti-CDX2 Recombinant Antibody (CAP474) (CBMAB-AP1424LY)

Datasheet SDS
Target: CDX2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: CAP474
Application*: ICC, IP, WB

Mouse Anti-CDX2 Recombinant Antibody (CAP473) (CBMAB-AP1423LY)

Datasheet SDS
Target: CDX2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Monkey, Mouse
Clone: CAP473
Application*: ELISA, ICC, IP, WB

Mouse Anti-CDX2 Recombinant Antibody (CAP472) (CBMAB-AP1422LY)

Datasheet SDS
Target: CDX2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: CAP472
Application*: ELISA, IHC, WB

Mouse Anti-CDX2 Recombinant Antibody (CAP471) (CBMAB-AP1421LY)

Datasheet SDS
Target: CDX2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: CAP471
Application*: ELISA, ICC, IP, WB

Mouse Anti-CDX2 Recombinant Antibody (CF093) (CBMAB-FT406LY)

Datasheet SDS
Target: CDX2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: CF093
Application*: ELISA, WB

Mouse Anti-CDX2 Recombinant Antibody (CB469A) (CBMAB-CA469LY)

Datasheet SDS
Target: CDX2
Host: Mouse
Antibody Isotype: lgG2b
Specificity: Human, Monkey, Mouse
Clone: CB469A
Application*: ELISA, WB, ICC, IP

Mouse Anti-CDX2 Recombinant Antibody (CB458A) (CBMAB-CA458LY)

Datasheet SDS
Target: CDX2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: CB458A
Application*: ELISA, WB, ICC, IP

Mouse Anti-CDX2 Recombinant Antibody (CB367A) (CBMAB-CA367LY)

Datasheet SDS
Target: CDX2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CB367A
Application*: ELISA, WB, IHC

Mouse Anti-CDX2 Recombinant Antibody (CB164) (CBMAB-CS164LY)

Datasheet SDS
Target: CDX2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CB164
Application*: WB, IHC

Mouse Anti-CDX2 Recombinant Antibody (IHC402) (CBMAB-MA063-YC)

Datasheet SDS
Target: CDX2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: IHC402
Application*: IH

Rabbit Anti-CDX2 Recombinant Antibody (D11D10) (CBMAB-CP0273-LY)

Datasheet SDS
Target: CDX2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D11D10
Application*: WB, IP, P, IF (IC)

Mouse Anti-CDX2 Recombinant Antibody (ZC007) (CBMAB-C10857-LY)

Datasheet SDS
Target: CDX2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: ZC007
Application*: E, P, WB

Mouse Anti-CDX2 Recombinant Antibody (13k30) (CBMAB-C2165-CN)

Datasheet SDS
Target: CDX2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: 13k30
Application*: IF, IP, WB

Mouse Anti-CDX2 Recombinant Antibody (CBYY-C1835) (CBMAB-C3273-YY)

Datasheet SDS
Target: CDX2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-C1835
Application*: IH

Mouse Anti-CDX2 Recombinant Antibody (CBYY-C1832) (CBMAB-C3270-YY)

Datasheet SDS
Target: CDX2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C1832
Application*: P, WB

Mouse Anti-CDX2 Recombinant Antibody (CBYY-C0734) (CBMAB-C2167-YY)

Datasheet SDS
Target: CDX2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0734
Application*: IH, IC

Mouse Anti-CDX2 Recombinant Antibody (8J980) (CBMAB-C9284-LY)

Datasheet SDS
Target: CDX2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 8J980
Application*: IH

Mouse Anti-CDX2 Recombinant Antibody (5A4E6) (CBMAB-C7269-LY)

Datasheet SDS
Target: CDX2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 5A4E6
Application*: E, WB

Mouse Anti-CDX2 Recombinant Antibody (4F12-B3-H4) (CBMAB-C6917-LY)

Datasheet SDS
Target: CDX2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: 4F12-B3-H4
Application*: IC/IF, IP, WB

Mouse Anti-CDX2 Recombinant Antibody (4B9-B12-E9) (CBMAB-C6702-LY)

Datasheet SDS
Target: CDX2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Monkey
Clone: 4B9-B12-E9
Application*: IC/IF, IP, WB

Mouse Anti-CDX2 Recombinant Antibody (3G9B9) (CBMAB-C6201-LY)

Datasheet SDS
Target: CDX2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3G9B9
Application*: WB, F

Mouse Anti-CDX2 Recombinant Antibody (3G4) (CBMAB-C6139-LY)

Datasheet SDS
Target: CDX2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 3G4
Application*: WB

Mouse Anti-CDX2 Recombinant Antibody (2G5) (CBMAB-C5190-LY)

Datasheet SDS
Target: CDX2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2G5
Application*: P, WB

Mouse Anti-CDX2 Recombinant Antibody (2G1) (CBMAB-C5139-LY)

Datasheet SDS
Target: CDX2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2G1
Application*: WB

Mouse Anti-CDX2 Recombinant Antibody (2F12A6) (CBMAB-C5064-LY)

Datasheet SDS
Target: CDX2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2F12A6
Application*: E, WB, P, IF/C, F

Mouse Anti-CDX2 Recombinant Antibody (1C7) (CBMAB-C3766-LY)

Datasheet SDS
Target: CDX2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 1C7
Application*: E, P, WB

Mouse Anti-CDX2 Recombinant Antibody (1A5) (CBMAB-C3552-LY)

Datasheet SDS
Target: CDX2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 1A5
Application*: WB, IH

Mouse Anti-CDX2 Recombinant Antibody (13k29) (CBMAB-C2941-LY)

Datasheet SDS
Target: CDX2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Monkey, Mouse
Clone: 13k29
Application*: IC, IP, WB

Mouse Anti-CDX2 Recombinant Antibody (14H6) (CBMAB-C0343-LY)

Datasheet SDS
Target: CDX2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 14H6
Application*: WB, IH
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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