CHRM5

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, stimulation of this receptor is known to increase cyclic AMP levels. [provided by RefSeq, Jul 2008]

Full Name

Cholinergic Receptor Muscarinic 5

Function

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

Biological Process

Adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway Source: GO_Central
Chemical synaptic transmission Source: GO_Central
Dopamine transport Source: Ensembl
Gastric acid secretion Source: InterPro
G protein-coupled acetylcholine receptor signaling pathway Source: ProtInc
G protein-coupled receptor signaling pathway Source: Reactome
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
Regulation of phosphatidylinositol dephosphorylation Source: Ensembl
Transmission of nerve impulse Source: Ensembl

Cellular Location

Cell membrane; Postsynaptic cell membrane

Topology

Extracellular: 1-29
Helical: 30-53
Cytoplasmic: 54-66
Helical: 67-87
Extracellular: 88-104
Helical: 105-126
Cytoplasmic: 127-146
Helical: 147-169
Extracellular: 170-191
Helical: 192-214
Cytoplasmic: 215-443
Helical: 444-464
Extracellular: 465-478
Helical: 479-498
Cytoplasmic: 499-532