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CLEC2D

This gene encodes a member of the natural killer cell receptor C-type lectin family. The encoded protein inhibits osteoclast formation and contains a transmembrane domain near the N-terminus as well as the C-type lectin-like extracellular domain. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Oct 2010]
Full Name
C-Type Lectin Domain Family 2 Member D
Function
Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis (PubMed:20843815, PubMed:16339513).

Inhibits osteoclast formation (PubMed:14753741, PubMed:15123656).

Inhibits bone resorption (PubMed:14753741).

Modulates the release of interferon-gamma (PubMed:15104121).

Binds high molecular weight sulfated glycosaminoglycans (PubMed:15123656).
Biological Process
Cell surface receptor signaling pathway Source: ProtInc
Regulation of immune response Source: Reactome
Cellular Location
Cell membrane
Isoform 2&4: Endoplasmic reticulum
Topology
Cytoplasmic: 1-38
Helical: 39-59
Extracellular: 60-191
PTM
N-glycosylated.

Anti-CLEC2D antibodies

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Mouse Anti-CLEC2D Recombinant Antibody (166C1309) (CBMAB-O0005-CQ)

Datasheet SDS
Target: CLEC2D
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse
Clone: 166C1309
Application*: WB

Mouse Anti-CLEC2D (AA 57-191) Recombinant Antibody (CBXO-0384) (CBMAB-O0131-CQ)

Datasheet SDS
Target: CLEC2D
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXO-0384
Application*: F

Mouse Anti-CLEC2D Recombinant Antibody (2E11) (CBMAB-C4963-LY)

Datasheet SDS
Target: CLEC2D
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2E11
Application*: E, WB

Mouse Anti-CLEC2D Recombinant Antibody (4C7) (CBMAB-C6743-LY)

Datasheet SDS
Target: CLEC2D
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4C7
Application*: E, P, WB

Mouse Anti-CLEC2D Recombinant Antibody (CBFYC-1920) (CBMAB-C1985-FY)

Datasheet SDS
Target: CLEC2D
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBFYC-1920
Application*: WB

CLEC2D Matched Antibody Pair (274) (APMAB-274LY)

Datasheet SDS
Target: CLEC2D
Specificity: Human

CLEC2D Matched Antibody Pair (275) (APMAB-275LY)

Datasheet SDS
Target: CLEC2D
Specificity: Human
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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