CLEC2D
This gene encodes a member of the natural killer cell receptor C-type lectin family. The encoded protein inhibits osteoclast formation and contains a transmembrane domain near the N-terminus as well as the C-type lectin-like extracellular domain. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Oct 2010]
                Full Name
                    C-Type Lectin Domain Family 2 Member D
                Function
                    Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis (PubMed:20843815, PubMed:16339513).
Inhibits osteoclast formation (PubMed:14753741, PubMed:15123656).
Inhibits bone resorption (PubMed:14753741).
Modulates the release of interferon-gamma (PubMed:15104121).
Binds high molecular weight sulfated glycosaminoglycans (PubMed:15123656).
                Inhibits osteoclast formation (PubMed:14753741, PubMed:15123656).
Inhibits bone resorption (PubMed:14753741).
Modulates the release of interferon-gamma (PubMed:15104121).
Binds high molecular weight sulfated glycosaminoglycans (PubMed:15123656).
Biological Process
                    Cell surface receptor signaling pathway Source: ProtInc
Regulation of immune response Source: Reactome
                Regulation of immune response Source: Reactome
Cellular Location
                    Cell membrane
Isoform 2&4: Endoplasmic reticulum
                Isoform 2&4: Endoplasmic reticulum
Topology
                    Cytoplasmic: 1-38
Helical: 39-59
Extracellular: 60-191
                Helical: 39-59
Extracellular: 60-191
PTM
                    N-glycosylated.
                
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                    Anti-CLEC2D antibodies
 + Filters
		
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        Target: CLEC2D
                
                Host: Mouse
                
                Antibody Isotype: IgG1
                
                Specificity: Mouse
                
                Clone: CBXO-0384
                
                Application*: WB
                
            Target: CLEC2D
                
                Host: Mouse
                
                Antibody Isotype: IgG1
                
                Specificity: Human
                
                Clone: CBFYC-1920
                
                Application*: F
                
            Target: CLEC2D
                
                Host: Mouse
                
                Antibody Isotype: IgG1, κ
                
                Specificity: Human
                
                Clone: 4C7
                
                Application*: E, P, WB
                
            Target: CLEC2D
                
                Host: Mouse
                
                Antibody Isotype: IgG2a, κ
                
                Specificity: Human
                
                Clone: 2E11
                
                Application*: E, WB
                
            Target: CLEC2D
                
                Host: Mouse
                
                Antibody Isotype: IgG1
                
                Specificity: Mouse
                
                Clone: O0005
                
                Application*: WB
                
            Target: CLEC2D
                
                Specificity: Human
                
            Target: CLEC2D
                
                Specificity: Human
                
            More Infomation
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For Research Use Only. Not For Clinical Use.
                    (P): Predicted
* Abbreviations 
- AActivation
 - AGAgonist
 - APApoptosis
 - BBlocking
 - BABioassay
 - BIBioimaging
 - CImmunohistochemistry-Frozen Sections
 - CIChromatin Immunoprecipitation
 - CTCytotoxicity
 - CSCostimulation
 - DDepletion
 - DBDot Blot
 
- EELISA
 - ECELISA(Cap)
 - EDELISA(Det)
 - ESELISpot
 - EMElectron Microscopy
 - FFlow Cytometry
 - FNFunction Assay
 - GSGel Supershift
 - IInhibition
 - IAEnzyme Immunoassay
 - ICImmunocytochemistry
 - IDImmunodiffusion
 - IEImmunoelectrophoresis
 
- IFImmunofluorescence
 - IGImmunochromatography
 - IHImmunohistochemistry
 - IMImmunomicroscopy
 - IOImmunoassay
 - IPImmunoprecipitation
 - ISIntracellular Staining for Flow Cytometry
 - LALuminex Assay
 - LFLateral Flow Immunoassay
 - MMicroarray
 - MCMass Cytometry/CyTOF
 - MDMeDIP
 
- MSElectrophoretic Mobility Shift Assay
 - NNeutralization
 - PImmunohistologyp-Paraffin Sections
 - PAPeptide Array
 - PEPeptide ELISA
 - PLProximity Ligation Assay
 - RRadioimmunoassay
 - SStimulation
 - SESandwich ELISA
 - SHIn situ hybridization
 - TCTissue Culture
 - WBWestern Blot
 
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