Mouse Anti-CLEC2D Recombinant Antibody (2E11) (V2LY-1206-LY109)

Name: Mouse Anti-CLEC2D Recombinant Antibody (2E11)
SKU: V2LY-1206-LY109
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

2E11

Antibody Isotype

IgG2a, κ

Application

ELISA, WB

Basic Information

Immunogen

Full-length recombinant CLEC2D.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

C-Type Lectin Domain Family 2 Member D

Entrez Gene ID

29121

UniProt ID

Q9UHP7

Function

Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis (PubMed:20843815, PubMed:16339513).

Inhibits osteoclast formation (PubMed:14753741, PubMed:15123656).

Inhibits bone resorption (PubMed:14753741).

Modulates the release of interferon-gamma (PubMed:15104121).

Binds high molecular weight sulfated glycosaminoglycans (PubMed:15123656).

Biological Process

Cell surface receptor signaling pathway Source: ProtInc
Regulation of immune response Source: Reactome

Cellular Location

Cell membrane
Isoform 2&4: Endoplasmic reticulum

Topology

Cytoplasmic: 1-38
Helical: 39-59
Extracellular: 60-191

PTM

N-glycosylated.

More Infomation

References

Lai, J. J., Cruz, F. M., & Rock, K. L. (2020). Immune sensing of cell death through recognition of histone sequences by C-type lectin-receptor-2d causes inflammation and tissue injury. Immunity, 52(1), 123-135.

Del Fresno, C., & Sancho, D. (2020). Clec2d Joins the Cell Death Sensor Ranks. Immunity, 52(1), 6-8.

Marrufo, A. M., Mathew, S. O., Chaudhary, P., Malaer, J. D., Vishwanatha, J. K., & Mathew, P. A. (2018). Blocking LLT1 (CLEC2D, OCIL)-NKRP1A (CD161) interaction enhances natural killer cell-mediated lysis of triple-negative breast cancer cells. American journal of cancer research, 8(6), 1050.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Antibody Pairs

CLEC2D Matched Antibody Pair (274)

CLEC2D Matched Antibody Pair (275)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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