Mouse Anti-CLEC2D Recombinant Antibody (O0005) (V2LY-1206-LY107)

Name: Mouse Anti-CLEC2D Recombinant Antibody (O0005)
SKU: V2LY-1206-LY107
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

O0005

Application

Immunogen

Amino acids 2-18 of OCIL of mouse.

Host Species

Mouse

Specificity

Mouse

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

0.1% gelatin

Preservative

<0.1% sodium azide

Concentration

0.1 mg/ml

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

C-Type Lectin Domain Family 2 Member D

Entrez Gene ID

93694

UniProt ID

Q91V08

Function

Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis (PubMed:20843815, PubMed:16339513).

Inhibits osteoclast formation (PubMed:14753741, PubMed:15123656).

Inhibits bone resorption (PubMed:14753741).

Modulates the release of interferon-gamma (PubMed:15104121).

Binds high molecular weight sulfated glycosaminoglycans (PubMed:15123656).

Biological Process

Cell surface receptor signaling pathway Source: ProtInc
Regulation of immune response Source: Reactome

Cellular Location

Cell membrane
Isoform 2&4: Endoplasmic reticulum

Topology

Cytoplasmic: 1-38
Helical: 39-59
Extracellular: 60-191

PTM

N-glycosylated.

Lai, J. J., Cruz, F. M., & Rock, K. L. (2020). Immune sensing of cell death through recognition of histone sequences by C-type lectin-receptor-2d causes inflammation and tissue injury. Immunity, 52(1), 123-135.

Del Fresno, C., & Sancho, D. (2020). Clec2d Joins the Cell Death Sensor Ranks. Immunity, 52(1), 6-8.

Marrufo, A. M., Mathew, S. O., Chaudhary, P., Malaer, J. D., Vishwanatha, J. K., & Mathew, P. A. (2018). Blocking LLT1 (CLEC2D, OCIL)-NKRP1A (CD161) interaction enhances natural killer cell-mediated lysis of triple-negative breast cancer cells. American journal of cancer research, 8(6), 1050.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

CLEC2D Matched Antibody Pair (274) (CAT#: APMAB-274LY)

CLEC2D Matched Antibody Pair (275) (CAT#: APMAB-275LY)

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CLEC2D Matched Antibody Pair (275) (CAT#: APMAB-275LY)

CLEC2D Matched Antibody Pair (274) (CAT#: APMAB-274LY)

Mouse Anti-CLEC2D Recombinant Antibody (4C7) (CAT#: V2LY-1206-LY110)

Mouse Anti-CLEC2D Recombinant Antibody (CBXO-0384) (CAT#: CBMAB-O0131-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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