CMBL

CMBL (EC 3.1.1.45) is a cysteine hydrolase of the dienelactone hydrolase family that is highly expressed in liver cytosol. CMBL preferentially cleaves cyclic esters, and it activates medoxomil-ester prodrugs in which the medoxomil moiety is linked to an oxygen atom (Ishizuka et al., 2010 [PubMed 20177059]).[supplied by OMIM, Apr 2010]

Full Name

Carboxymethylenebutenolidase Homolog

Function

Cysteine hydrolase. Can convert the prodrug olmesartan medoxomil into its pharmacologically active metabolite olmerstatan, an angiotensin receptor blocker, in liver and intestine. May also activate beta-lactam antibiotics faropenem medoxomil and lenampicillin.

Biological Process

Xenobiotic metabolic process Source: Reactome

Cellular Location

Cytosol

Anti-CMBL antibodies

Mouse Anti-CMBL Recombinant Antibody (CBWJC-2836) (CBMAB-C3958WJ)

Datasheet

SDS

Target: CMBL

Host: Mouse

Antibody Isotype: IgG

Specificity: Mouse, Rat, Human

Clone: CBWJC-2836

Application*: WB, IP, IF, E

Mouse Anti-CMBL (AA 1-245) Recombinant Antibody (CBFYC-0520) (CBMAB-C0571-FY)

Datasheet

SDS

Target: CMBL

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYC-0520

Application*: WB, E

Mouse Anti-CMBL Recombinant Antibody (CAP1021) (CBMAB-AP1558LY)

Datasheet

SDS

Target: CMBL

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CAP1021

Application*: Dot blot, ELISA, WB

Mouse Anti-CMBL Recombinant Antibody (PAT2B11AT) (CBMAB-C11060-LY)

Datasheet

SDS

Target: CMBL

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: PAT2B11AT

Application*: E

Mouse Anti-CMBL Recombinant Antibody (16C30) (CBMAB-C3355-LY)

Datasheet

SDS

Target: CMBL

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 16C30

Application*: E, WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)