DHFR

Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2014]
Full Name
dihydrofolate reductase
Function
Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2.
Biological Process
Axon regeneration Source: BHF-UCL
Dihydrofolate metabolic process Source: BHF-UCL
Folic acid metabolic process Source: BHF-UCL
Glycine biosynthetic process Source: InterPro
Negative regulation of translation Source: CAFA
One-carbon metabolic process Source: UniProtKB-KW
Positive regulation of nitric-oxide synthase activity Source: BHF-UCL
Regulation of removal of superoxide radicals Source: BHF-UCL
Regulation of transcription involved in G1/S transition of mitotic cell cycle Source: Reactome
Response to methotrexate Source: BHF-UCL
Tetrahydrobiopterin biosynthetic process Source: BHF-UCL
Tetrahydrofolate biosynthetic process Source: BHF-UCL
Tetrahydrofolate metabolic process Source: UniProtKB
Cellular Location
Cytoplasm; Mitochondrion
Involvement in disease
Megaloblastic anemia due to dihydrofolate reductase deficiency (DHFRD):
An inborn error of metabolism, characterized by megaloblastic anemia and/or pancytopenia, severe cerebral folate deficiency, and cerebral tetrahydrobiopterin deficiency. Clinical features include variable neurologic symptoms, ranging from severe developmental delay and generalized seizures in infancy, to childhood absence epilepsy with learning difficulties, to lack of symptoms.
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Anti-DHFR antibodies

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Mouse Anti-DHFR Recombinant Antibody (D0821) (CBMAB-D0821-YC)

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Target: DHFR
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: D0821
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-DHFR Recombinant Antibody (3C8) (CBMAB-BR157LY)

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Target: DHFR
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: 3C8
Application*: WB, IP, IF, E, P
Datasheet SDS

Mouse Anti-DHFR Recombinant Antibody (D0823) (V2LY-0425-LY271)

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Target: DHFR
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: D0823
Application*: WB, IP, IF, E, P
Datasheet SDS

Mouse Anti-DHFR Recombinant Antibody (CBYCD-259) (V2LY-0425-LY270)

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Target: DHFR
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBYCD-259
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-DHFR Recombinant Antibody (5B2) (V2LY-0425-LY268)

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Target: DHFR
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Rat
Clone: 5B2
Application*: WB, IH
Datasheet SDS

Mouse Anti-DHFR Recombinant Antibody (D0819) (V2LY-0425-LY267)

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Target: DHFR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: D0819
Application*: IF, WB, F
Datasheet SDS

Mouse Anti-DHFR Recombinant Antibody (D0818) (V2LY-0425-LY266)

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Target: DHFR
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: D0818
Application*: IF, P, WB
Datasheet SDS

Mouse Anti-DHFR Recombinant Antibody (D0817) (V2LY-0425-LY265)

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Target: DHFR
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: D0817
Application*: IF, WB, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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