EIF4EBP1
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008]
Full Name
Eukaryotic Translation Initiation Factor 4E Binding Protein 1
Research Area
Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
Biological Process
Cellular response to hypoxia Source: Ensembl
G1/S transition of mitotic cell cycle Source: UniProtKB
Lung development Source: Ensembl
Negative regulation of protein-containing complex assembly Source: Ensembl
Negative regulation of translational initiation Source: UniProtKB
Positive regulation of mitotic cell cycle Source: UniProtKB
Response to amino acid starvation Source: Ensembl
Response to ethanol Source: Ensembl
Response to ischemia Source: Ensembl
TOR signaling Source: UniProtKB
G1/S transition of mitotic cell cycle Source: UniProtKB
Lung development Source: Ensembl
Negative regulation of protein-containing complex assembly Source: Ensembl
Negative regulation of translational initiation Source: UniProtKB
Positive regulation of mitotic cell cycle Source: UniProtKB
Response to amino acid starvation Source: Ensembl
Response to ethanol Source: Ensembl
Response to ischemia Source: Ensembl
TOR signaling Source: UniProtKB
Cellular Location
Cytosol; Postsynaptic cytosol; Nucleus; Cytoplasm; Glutamatergic synapse; Protein-containing complex
PTM
Phosphorylated on serine and threonine residues in response to insulin, EGF and PDGF. Phosphorylation at Thr-37, Thr-46, Ser-65 and Thr-70, corresponding to the hyperphosphorylated form, is regulated by mTORC1 and abolishes binding to EIF4E.
Ubiquitinated: when eIF4E levels are low, hypophosphorylated form is ubiquitinated by the BCR(KLHL25) complex, leading to its degradation and serving as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. Not ubiquitinated when hyperphosphorylated (at Thr-37, Thr-46, Ser-65 and Thr-70) or associated with eIF4E.
Ubiquitinated: when eIF4E levels are low, hypophosphorylated form is ubiquitinated by the BCR(KLHL25) complex, leading to its degradation and serving as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. Not ubiquitinated when hyperphosphorylated (at Thr-37, Thr-46, Ser-65 and Thr-70) or associated with eIF4E.
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Anti-EIF4EBP1 antibodies
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CompareTarget: EIF4EBP1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: 10
Application*: WB, IF, IP, P, E
Target: EIF4EBP1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT91
Application*: WB, P, IF, E
Target: EIF4EBP1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT92
Application*: WB, P, IF, E
Target: EIF4EBP1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT93
Application*: WB, E
Target: EIF4EBP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3953
Application*: WB
Target: EIF4EBP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2781
Application*: IH
Target: EIF4EBP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4374
Application*: IH
Target: EIF4EBP1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 4F3-H2
Application*: E, IF, PLA, WB
Target: EIF4EBP1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLQE-001
Application*: WB, E
Target: EIF4EBP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 17
Application*: WB, E, IF
Target: EIF4EBP1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 6I
Application*: IF
Target: EIF4EBP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 12D9
Application*: F
Target: EIF4EBP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 13B3
Application*: IF
Target: EIF4EBP1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat, Pig
Clone: CBFYE-0725
Application*: WB, IF, IP, P, E
Target: EIF4EBP1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYE-0186
Application*: WB, IF, IP, P
Target: EIF4EBP1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 6
Application*: WB
Target: EIF4EBP1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: 11
Application*: WB, IP, E
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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