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EZH1

EZH1 is a component of a noncanonical Polycomb repressive complex-2 (PRC2) that mediates methylation of histone H3 (see MIM 602812) lys27 (H3K27) and functions in the maintenance of embryonic stem cell pluripotency and plasticity (Shen et al., 2008 [PubMed 19026780]).[supplied by OMIM, Mar 2009]
Full Name
Enhancer Of Zeste 1 Polycomb Repressive Complex 2 Subunit
Research Area
Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation.
Biological Process
Anatomical structure morphogenesis Source: ProtInc
Chromatin remodeling Source: ARUK-UCL
Chromatin silencing at telomere Source: ARUK-UCL
Heterochromatin assembly Source: ARUK-UCL
Hippocampus development Source: Ensembl
Histone H3-K27 methylation Source: InterPro
Negative regulation of transcription by RNA polymerase II Source: ARUK-UCL
Positive regulation of transcription by RNA polymerase II Source: Ensembl
Cellular Location
Nucleus. Colocalizes with trimethylated 'Lys-27' of histone H3.
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Anti-EZH1 antibodies

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Mouse Anti-EZH1 Recombinant Antibody (A12) (CBMAB-E2055-FY)

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Target: EZH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: A12
Application*: E, WB, F
Datasheet SDS

Mouse Anti-EZH1 Recombinant Antibody (CBT2979) (V2LY-0625-LY1188)

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Target: EZH1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBT2979
Application*: F
Datasheet SDS

Mouse Anti-EZH1 Recombinant Antibody (CBT3068) (V2LY-0625-LY1187)

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Target: EZH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3068
Application*: WB, F
Datasheet SDS

Mouse Anti-EZH1 Recombinant Antibody (EG1155) (CBMAB-EN1385-LY)

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Target: EZH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: EG1155
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-EZH1 Recombinant Antibody (1C) (CBMAB-CP3106-LY)

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Target: EZH1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 1C
Application*: WB, IP, IF, E
Datasheet SDS

Rabbit Anti-EZH1 Recombinant Antibody (5D) (CBMAB-CP0656-LY)

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Target: EZH1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: 5D
Application*: WB, IP
Datasheet SDS

Mouse Anti-EZH1 Recombinant Antibody (CBFYE-1429) (CBMAB-E2054-FY)

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Target: EZH1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYE-1429
Application*: E, F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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