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EZH1

EZH1 is a component of a noncanonical Polycomb repressive complex-2 (PRC2) that mediates methylation of histone H3 (see MIM 602812) lys27 (H3K27) and functions in the maintenance of embryonic stem cell pluripotency and plasticity (Shen et al., 2008 [PubMed 19026780]).[supplied by OMIM, Mar 2009]

Full Name

Enhancer Of Zeste 1 Polycomb Repressive Complex 2 Subunit

Research Area

Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation.

Biological Process

Anatomical structure morphogenesis Source: ProtInc
Chromatin remodeling Source: ARUK-UCL
Chromatin silencing at telomere Source: ARUK-UCL
Heterochromatin assembly Source: ARUK-UCL
Hippocampus development Source: Ensembl
Histone H3-K27 methylation Source: InterPro
Negative regulation of transcription by RNA polymerase II Source: ARUK-UCL
Positive regulation of transcription by RNA polymerase II Source: Ensembl

Cellular Location

Nucleus. Colocalizes with trimethylated 'Lys-27' of histone H3.

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Anti-EZH1 antibodies

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Mouse Anti-EZH1 Recombinant Antibody (A12) (CBMAB-E2055-FY)

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Target: EZH1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: A12

Application*: E, WB, F

Mouse Anti-EZH1 Recombinant Antibody (CBT2979) (V2LY-0625-LY1188)

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Target: EZH1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBT2979

Application*: F

Mouse Anti-EZH1 Recombinant Antibody (CBT3068) (V2LY-0625-LY1187)

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Target: EZH1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBT3068

Application*: WB, F

Mouse Anti-EZH1 Recombinant Antibody (EG1155) (CBMAB-EN1385-LY)

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Target: EZH1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: EG1155

Application*: WB, IP, IF, E

Mouse Anti-EZH1 Recombinant Antibody (1C) (CBMAB-CP3106-LY)

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Target: EZH1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse, Rat

Clone: 1C

Application*: WB, IP, IF, E

Rabbit Anti-EZH1 Recombinant Antibody (5D) (CBMAB-CP0656-LY)

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Target: EZH1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Monkey

Clone: 5D

Application*: WB, IP

Mouse Anti-EZH1 Recombinant Antibody (CBFYE-1429) (CBMAB-E2054-FY)

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Target: EZH1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBFYE-1429

Application*: E, F

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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