EZH1

EZH1 is a component of a noncanonical Polycomb repressive complex-2 (PRC2) that mediates methylation of histone H3 (see MIM 602812) lys27 (H3K27) and functions in the maintenance of embryonic stem cell pluripotency and plasticity (Shen et al., 2008 [PubMed 19026780]).[supplied by OMIM, Mar 2009]

Enhancer Of Zeste 1 Polycomb Repressive Complex 2 Subunit

Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation.

Anatomical structure morphogenesis Source: ProtInc
Chromatin remodeling Source: ARUK-UCL
Chromatin silencing at telomere Source: ARUK-UCL
Heterochromatin assembly Source: ARUK-UCL
Hippocampus development Source: Ensembl
Histone H3-K27 methylation Source: InterPro
Negative regulation of transcription by RNA polymerase II Source: ARUK-UCL
Positive regulation of transcription by RNA polymerase II Source: Ensembl

Nucleus. Colocalizes with trimethylated 'Lys-27' of histone H3.