GYPC

Glycophorin C (GYPC) is an integral membrane glycoprotein. It is a minor species carried by human erythrocytes, but plays an important role in regulating the mechanical stability of red cells. A number of glycophorin C mutations have been described. The Gerbich and Yus phenotypes are due to deletion of exon 3 and 2, respectively. The Webb and Duch antigens, also known as glycophorin D, result from single point mutations of the glycophorin C gene. The glycophorin C protein has very little homology with glycophorins A and B. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
Full Name
Glycophorin C (Gerbich Blood Group)
Function
This protein is a minor sialoglycoprotein in human erythrocyte membranes. The blood group Gerbich antigens and receptors for Plasmodium falciparum merozoites are most likely located within the extracellular domain. Glycophorin-C plays an important role in regulating the stability of red cells.
Cellular Location
Cell membrane. Linked to the membrane via band 4.1.
Topology
Extracellular: 1-57
Helical: 58-81
Cytoplasmic: 82-128
PTM
O-glycosylated with core 1 or possibly core 8 glycans.
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Anti-GYPC antibodies

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Mouse Anti-GYPC Recombinant Antibody (1H3) (CBMAB-G5860-LY)

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Target: GYPC
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1H3
Application*: WB, IF, IP, F
Datasheet SDS

Rabbit Anti-GYPC Recombinant Antibody (4) (CBMAB-G0971-LY)

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Target: GYPC
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 4
Application*: WB, IF, IP
Datasheet SDS

Mouse Anti-GYPC Recombinant Antibody (CB250) (CBMAB-AL250LY)

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Target: GYPC (Concentrate)
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CB250
Application*: WB, IF, IP
Datasheet SDS

Mouse Anti-GYPC Recombinant Antibody (3H2) (CBMAB-C6276-LY)

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Target: GYPC
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 3H2
Application*: WB, F, IP
Datasheet SDS

Rabbit Anti-GYPC Recombinant Antibody (CBFYH-2998) (CBMAB-H1432-FY)

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Target: GYPC
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYH-2998
Application*: WB, IH
Datasheet SDS

Mouse Anti-GYPC Recombinant Antibody (CBFYH-2997) (CBMAB-H0090-FY)

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Target: GYPC
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYH-2997
Application*: WB, IP, F
Datasheet SDS

Mouse Anti-GYPC Recombinant Antibody (CBFYH-2996) (CBMAB-H0089-FY)

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Target: GYPC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2996
Application*: WB, F, IH
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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