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GYPC

Glycophorin C (GYPC) is an integral membrane glycoprotein. It is a minor species carried by human erythrocytes, but plays an important role in regulating the mechanical stability of red cells. A number of glycophorin C mutations have been described. The Gerbich and Yus phenotypes are due to deletion of exon 3 and 2, respectively. The Webb and Duch antigens, also known as glycophorin D, result from single point mutations of the glycophorin C gene. The glycophorin C protein has very little homology with glycophorins A and B. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]

Full Name

Glycophorin C (Gerbich Blood Group)

Function

This protein is a minor sialoglycoprotein in human erythrocyte membranes. The blood group Gerbich antigens and receptors for Plasmodium falciparum merozoites are most likely located within the extracellular domain. Glycophorin-C plays an important role in regulating the stability of red cells.

Cellular Location

Cell membrane. Linked to the membrane via band 4.1.

Topology

Extracellular: 1-57
Helical: 58-81
Cytoplasmic: 82-128

PTM

O-glycosylated with core 1 or possibly core 8 glycans.

Anti-GYPC antibodies

Mouse Anti-GYPC Monoclonal Antibody (CBFYH-2996) (CBMAB-H0089-FY)

SDS

Target: GYPC

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYH-2996

Application*: WB, F

Mouse Anti-GYPC Monoclonal Antibody (CBFYH-2997) (CBMAB-H0090-FY)

SDS

Target: GYPC

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYH-2997

Application*: WB, F, IH, C

Mouse Anti-GYPC Monoclonal Antibody (CBFYH-2998) (CBMAB-H1432-FY)

SDS

Target: GYPC

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYH-2998

Application*: WB, IH, C

Mouse Anti-GYPC Recombinant Antibody (3H2008) (CBMAB-C6276-LY)

SDS

Target: GYPC

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 3H2008

Application*: WB, C, F

Mouse Anti-GYPC Recombinant Antibody (CBYY-C2528) (CBMAB-C3969-YY)

SDS

Target: GYPC

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-C2528

Application*: WB, IH, F

Mouse Anti-GYPC Recombinant Antibody (CBWJC-3753) (CBMAB-C5018WJ)

SDS

Target: GYPC

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBWJC-3753

Application*: C, WB, IP

Mouse Anti-GYPC Recombinant Antibody (CBWJC-3755) (CBMAB-C5020WJ)

SDS

Target: GYPC

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBWJC-3755

Application*: C, IP, WB

Mouse Anti-GYPC Recombinant Antibody (CBWJC-3756) (CBMAB-C5021WJ)

SDS

Target: GYPC

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBWJC-3756

Application*: F, WB, F

Mouse Anti-GYPC Recombinant Antibody (3H2007) (CBMAB-C3545-CN)

SDS

Target: GYPC

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 3H2007

Application*: IH, IP, WB

Mouse Anti-GYPC Recombinant Antibody (BRIC4) (CBMAB-G0971-LY)

SDS

Target: GYPC

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: BRIC4

Application*: WB

Mouse Anti-GYPC Recombinant Antibody (CBLG1-291) (CBMAB-G0972-LY)

SDS

Target: GYPC

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBLG1-291

Application*: IH, IP, WB

Mouse Anti-GYPC Recombinant Antibody (1H3) (CBMAB-G5860-LY)

SDS

Target: GYPC

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1H3

Application*: E, WB

Mouse Anti-GYPC Recombinant Antibody (B1249M) (CBMAB-G5863-LY)

SDS

Target: GYPC

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: B1249M

Application*: C, P

Mouse Anti-GYPC Recombinant Antibody (CBLG1-2180) (CBMAB-G5869-LY)

SDS

Target: GYPC

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBLG1-2180

Application*: F

Mouse Anti-GYPC Recombinant Antibody (CBLG1-2184) (CBMAB-G5873-LY)

SDS

Target: GYPC

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBLG1-2184

Application*: C, IP, WB

Mouse Anti-GYPC Recombinant Antibody (CBLG1-2185) (CBMAB-G5874-LY)

SDS

Target: GYPC

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBLG1-2185

Application*: IH, IP, WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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