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Mouse Anti-GYPC Monoclonal Antibody (CBFYH-2998) (CBMAB-H1432-FY)

This product is mouse antibody that recognizes GYPC. The antibody CBFYH-2998 can be used for immunoassay techniques such as: WB, IHC, IHC-Fr.
See all GYPC antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-2998
Antibody Isotype
IgG1
Application
WB, IHC, IHC-Fr

Basic Information

Immunogen
Synthetic peptide corresponding to amino acids in the cytoplasmic domain of GPC
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Glycophorin C (Gerbich Blood Group)
Introduction
Glycophorin C (GYPC) is an integral membrane glycoprotein. It is a minor species carried by human erythrocytes, but plays an important role in regulating the mechanical stability of red cells. A number of glycophorin C mutations have been described. The Gerbich and Yus phenotypes are due to deletion of exon 3 and 2, respectively. The Webb and Duch antigens, also known as glycophorin D, result from single point mutations of the glycophorin C gene. The glycophorin C protein has very little homology with glycophorins A and B. Alternate splicing results in multiple transcript variants.
Entrez Gene ID
2995
UniProt ID
P04921
Alternative Names
Glycophorin C (Gerbich Blood Group); Sialoglycoprotein D; Glycoprotein Beta; Glycoconnectin; Glycophorin-D; PAS-2; GPD; GPC; GE:GPC:GPD:GYPD
Function
This protein is a minor sialoglycoprotein in human erythrocyte membranes. The blood group Gerbich antigens and receptors for Plasmodium falciparum merozoites are most likely located within the extracellular domain. Glycophorin-C plays an important role in regulating the stability of red cells.
Cellular Location
Cell membrane. Linked to the membrane via band 4.1.
Topology
Extracellular: 1-57
Helical: 58-81
Cytoplasmic: 82-128
PTM
O-glycosylated with core 1 or possibly core 8 glycans.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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