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Rabbit Anti-GYPC Recombinant Antibody (4) (CBMAB-G0971-LY)

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Datasheet
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Basic Information

Host Animal
Rabbit
Clone
4
Application
WB, IF, IP
Immunogen
Human GYPC.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, BSA, glycerol
Preservative
Sodium azide
Concentration
1 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
Glycophorin C (Gerbich Blood Group)
Introduction
Glycophorin C (GYPC) is an integral membrane glycoprotein. It is a minor species carried by human erythrocytes, but plays an important role in regulating the mechanical stability of red cells. A number of glycophorin C mutations have been described. The Gerbich and Yus phenotypes are due to deletion of exon 3 and 2, respectively. The Webb and Duch antigens, also known as glycophorin D, result from single point mutations of the glycophorin C gene. The glycophorin C protein has very little homology with glycophorins A and B. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
Entrez Gene ID
2995
UniProt ID
P04921
Alternative Names
Glycophorin C (Gerbich Blood Group); Sialoglycoprotein D; Glycoprotein Beta; Glycoconnectin; Glycophorin-D; PAS-2; GPD; GPC; GE:GPC:GPD:GYPD;
Function
This protein is a minor sialoglycoprotein in human erythrocyte membranes. The blood group Gerbich antigens and receptors for Plasmodium falciparum merozoites are most likely located within the extracellular domain. Glycophorin-C plays an important role in regulating the stability of red cells.
Cellular Location
Cell membrane. Linked to the membrane via band 4.1.
Topology
Extracellular: 1-57
Helical: 58-81
Cytoplasmic: 82-128
PTM
O-glycosylated with core 1 or possibly core 8 glycans.

Rahman, M. S., Biswas, P. K., Saha, S. K., & Moni, M. A. (2022). Identification of glycophorin C as a prognostic marker for human breast cancer using bioinformatic analysis. Network Modeling Analysis in Health Informatics and Bioinformatics, 11(1), 7.

Lin, J. J., Loucks, C. M., Trueman, J. N., Drögemöller, B. I., Wright, G. E., Yoshida, E. M., ... & Carleton, B. C. (2021). Novel variant in glycophorin c gene protects against ribavirin-induced anemia during chronic hepatitis C treatment. Biomedicine & Pharmacotherapy, 143, 112195.

Karatas, M., Ulusan, M., & Demokan, S. (2021). P-10 Methylation-Based Expression Loss of Glycophorin C (GYPC) Gene and Clinical Importance in Oral Cancer. Oral Oncology, 118, 4.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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