HIV-1 gp41

Acts as a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During fusion of viral and target intracellular membranes, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes. Complete fusion occurs in host cell endosomes and is dynamin-dependent, however some lipid transfer might occur at the plasma membrane. The virus undergoes clathrin-dependent internalization long before endosomal fusion, thus minimizing the surface exposure of conserved viral epitopes during fusion and reducing the efficacy of inhibitors targeting these epitopes. Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm.

Full Name

Envelope glycoprotein GP41

Function

Biological Process

Actin filament reorganization Source: UniProtKB-UniRule
Clathrin-dependent endocytosis of virus by host cell Source: UniProtKB
Fusion of virus membrane with host endosome membrane Source: UniProtKB-UniRule
Fusion of virus membrane with host plasma membrane Source: UniProtKB
Mitigation of host immune response by virus Source: UniProtKB-UniRule
Positive regulation of establishment of T cell polarity Source: UniProtKB-UniRule
Positive regulation of plasma membrane raft polarization Source: UniProtKB-UniRule
Positive regulation of receptor clustering Source: UniProtKB-UniRule
Viral protein processing Source: UniProtKB
Virion attachment to host cell Source: UniProtKB

Cellular Location

Virion membrane; Host cell membrane; Host endosome membrane. The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag.

PTM

Highly glycosylated by host. The high number of glycan on the protein is reffered to as 'glycan shield' because it contributes to hide protein sequence from adaptive immune system.
Palmitoylation of the transmembrane protein and of Env polyprotein (prior to its proteolytic cleavage) is essential for their association with host cell membrane lipid rafts. Palmitoylation is therefore required for envelope trafficking to classical lipid rafts, but not for viral replication.
Specific enzymatic cleavages in vivo yield mature proteins. Envelope glycoproteins are synthesized as a inactive precursor that is heavily N-glycosylated and processed likely by host cell furin in the Golgi to yield the mature SU and TM proteins. The cleavage site between SU and TM requires the minimal sequence [KR]-X-[KR]-R. About 2 of the 9 disulfide bonds of gp41 are reduced by P4HB/PDI, following binding to CD4 receptor.

Anti-HIV-1 gp41 antibodies

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Human Anti-HIV-1 gp41 Recombinant Antibody (4E10) (CBMAB-YT098LY)

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Target: HIV-1 gp41

Host: Human

Antibody Isotype: IgG1

Specificity: HIV-1

Clone: 4E10

Application*: Neut., ELISA, IP, IF

HIV-1 gp41

Anti-HIV-1 gp41 antibodies

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