ITGAE
Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008]
Full Name
Integrin Subunit Alpha E
Function
Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers.
Biological Process
Cell adhesionIEA:UniProtKB-KW
Integrin-mediated signaling pathwayIEA:UniProtKB-KW
Integrin-mediated signaling pathwayIEA:UniProtKB-KW
Cellular Location
Membrane
Topology
Extracellular: 19-1124
Helical: 1125-1147
Cytoplasmic: 1148-1179
Helical: 1125-1147
Cytoplasmic: 1148-1179
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Anti-ITGAE antibodies
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CompareTarget: ITGAE
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: A676
Application*: FC, IHC, IP
Target: ITGAE
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: B-ly7
Application*: FC
Target: ITGAE
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Monkey
Clone: 3H1798
Application*: FC, IH, IP
Target: ITGAE
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBWJC-2227
Application*: B, IF, F
Target: ITGAE
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJC-2226
Application*: IF, IP, F
Target: ITGAE
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJC-2225
Application*: F, C
Target: ITGAE
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0149
Application*: F, IH, IP
Target: ITGAE
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBFYC-2809
Application*: F, IP
Target: ITGAE
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBFYC-2808
Application*: F, IH
Target: ITGAE
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: 7A3
Application*: P, F
Target: ITGAE
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 2G5.1
Application*: F, C, IP
Target: ITGAE
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: 14L142
Application*: F, IH
Target: ITGAE
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: 14L141
Application*: F, IP
Target: ITGAE
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3H1797
Application*: F, IH, IP
Target: ITGAE
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: 2E7
Application*: C, FN, P, F
Target: ITGAE
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: OX62
Application*: F, C, IP
Target: ITGAE
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYY-I1231
Application*: F, IH
Target: ITGAE
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: Ber-ACT8
Application*: WB, F, IH, IP, C, MC
Target: ITGAE
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: AX.14
Application*: F
Target: ITGAE
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: AP-MAB0828
Application*: IP, C, F, I, MC
Target: ITGAE
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: 6B8
Application*: E, WB
Target: ITGAE
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: BP6
Application*: IH, IP, IF
Target: ITGAE
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-I0501
Application*: F, IH, C
Target: ITGAE
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYY-I0446
Application*: F, IH, P, MC
Target: ITGAE
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: OX-62
Application*: F, IH, C, IP, WB
Target: ITGAE
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: LF61
Application*: F, C, IP
Target: ITGAE
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBYY-I0266
Application*: WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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