JMY

JMY (Junction Mediating And Regulatory Protein, P53 Cofactor) is a protein coding gene. Among its related pathways are Gene Expression and Direct p53 effectors. Gene Ontology annotations related to this gene include actin binding and transcription coactivator activity. An important paralog of this gene is WHAMM.

junction mediating and regulatory protein, p53 cofactor

Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions (PubMed:30420355).
In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments (PubMed:30420355).
Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments (PubMed:30420355).
Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. Upon nutrient stress, directly recruited by MAP1LC3B to the phagophore membrane surfaces to promote actin assembly during autophagy (PubMed:30420355).
The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location (By similarity).

de novo' actin filament nucleationISS:UniProtKB
Actin polymerization-dependent cell motilityISS:UniProtKB
Arp2/3 complex-mediated actin nucleationISS:UniProtKB
Cellular response to starvationManual Assertion Based On ExperimentIMP:UniProtKB
DNA repairIEA:UniProtKB-KW
Intrinsic apoptotic signaling pathway by p53 class mediatorISS:UniProtKB
Positive regulation of apoptotic processISS:UniProtKB
Positive regulation of DNA-binding transcription factor activityISS:UniProtKB
Regulation of transcription by RNA polymerase IIISS:HGNC-UCL

Nucleus; Cytoplasmic vesicle; Cytoplasm, cytoskeleton; Endomembrane system; Cytoplasmic vesicle, autophagosome membrane. Localizes to the nucleus in most cell types. Accumulates in nucleus under DNA damage conditions, increasing p53/TP53 transcription response and reducing its influence on cell motility (By similarity).
In primary neutrophils, it colocalizes with actin filaments at the leading edge and is excluded from the nucleus. Localization correlates with motility, because it moves from the nucleus to the cytoplasmic compartment when cells are differentiated from nonmotile cells into highly motile neutrophil-like cells. Localizes to cytoplasmic vesicles which associate with actin filament and autophagosomal membranes upon starvation-induced autophagy (PubMed:30420355).

Ubiquitinated by MDM2, leading to its subsequent degradation by the proteasome. In case of DNA damage, the interaction with MDM2 is altered, preventing degradation and allowing interaction with p300/EP300 and its function in p53/TP53 stress response (By similarity).