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KRAS

This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region.
Full Name
KRAS
Function
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:20949621).
Plays an important role in the regulation of cell proliferation (PubMed:23698361, PubMed:22711838).
Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner (PubMed:24623306).
Biological Process
Actin cytoskeleton organizationIEA:Ensembl
Endocrine signalingIEA:Ensembl
Epithelial tube branching involved in lung morphogenesisIEA:Ensembl
Forebrain astrocyte developmentIEA:Ensembl
Homeostasis of number of cells within a tissueIEA:Ensembl
MAPK cascadeTAS:Reactome
Negative regulation of cell differentiationIEA:Ensembl
Negative regulation of neuron apoptotic processIEA:Ensembl
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of gene expressionManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of protein phosphorylationManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of Rac protein signal transductionIEA:Ensembl
Ras protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Regulation of long-term neuronal synaptic plasticityIEA:Ensembl
Regulation of protein stabilityManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of synaptic transmission, GABAergicIEA:Ensembl
Striated muscle cell differentiationIEA:Ensembl
Visual learningIEA:Ensembl
Cellular Location
Cell membrane
Cytoplasm, cytosol
Isoform 2B:
Cell membrane
Involvement in disease
Leukemia, acute myelogenous (AML):
A subtype of acute leukemia, a cancer of the white blood cells. AML is a malignant disease of bone marrow characterized by maturational arrest of hematopoietic precursors at an early stage of development. Clonal expansion of myeloid blasts occurs in bone marrow, blood, and other tissue. Myelogenous leukemias develop from changes in cells that normally produce neutrophils, basophils, eosinophils and monocytes.
Leukemia, juvenile myelomonocytic (JMML):
An aggressive pediatric myelodysplastic syndrome/myeloproliferative disorder characterized by malignant transformation in the hematopoietic stem cell compartment with proliferation of differentiated progeny. Patients have splenomegaly, enlarged lymph nodes, rashes, and hemorrhages.
Noonan syndrome 3 (NS3):
A form of Noonan syndrome, a disease characterized by short stature, facial dysmorphic features such as hypertelorism, a downward eyeslant and low-set posteriorly rotated ears, and a high incidence of congenital heart defects and hypertrophic cardiomyopathy. Other features can include a short neck with webbing or redundancy of skin, deafness, motor delay, variable intellectual deficits, multiple skeletal defects, cryptorchidism, and bleeding diathesis. Individuals with Noonan syndrome are at risk of juvenile myelomonocytic leukemia, a myeloproliferative disorder characterized by excessive production of myelomonocytic cells.
Gastric cancer (GASC):
A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease.
Defects in KRAS are a cause of pylocytic astrocytoma (PA). Pylocytic astrocytomas are neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors.
Cardiofaciocutaneous syndrome 2 (CFC2):
A form of cardiofaciocutaneous syndrome, a multiple congenital anomaly disorder characterized by a distinctive facial appearance, heart defects and mental retardation. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy. Some affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal bridge, and posteriorly angulated ears with prominent helices. CFC2 patients often do not have the skin abnormalities, such as ichthyosis, hyperkeratosis, and hemangioma observed in CFC1.
KRAS mutations are involved in cancer development.
Oculoectodermal syndrome (OES):
A syndrome characterized by the association of epibulbar dermoids and aplasia cutis congenita. Affected individuals show multiple, asymmetric, atrophic, non-scarring and hairless regions that may be associated with hamartomas. Ectodermal changes include linear hyperpigmentation that may follow the lines of Blaschko and rarely epidermal nevus-like lesions. Epibulbar dermoids may be uni-or bilateral. Additional ocular anomalies such as skin tags of the upper eyelid, rarely optic nerve or retinal changes, and microphthalmia can be present. The phenotypic expression is highly variable, and various other abnormalities have occasionally been reported including growth failure, lymphedema, cardiovascular defects, as well as neurodevelopmental symptoms like developmental delay, epilepsy, learning difficulties, and behavioral abnormalities. Benign tumor-like lesions such as nonossifying fibromas of the long bones and giant cell granulomas of the jaws have repeatedly been observed and appear to be age-dependent, becoming a common manifestation in individuals aged 5 years or older.
Schimmelpenning-Feuerstein-Mims syndrome (SFM):
A disease characterized by sebaceous nevi, often on the face, associated with variable ipsilateral abnormalities of the central nervous system, ocular anomalies, and skeletal defects. Many oral manifestations have been reported, not only including hypoplastic and malformed teeth, and mucosal papillomatosis, but also ankyloglossia, hemihyperplastic tongue, intraoral nevus, giant cell granuloma, ameloblastoma, bone cysts, follicular cysts, oligodontia, and odontodysplasia. Sebaceous nevi follow the lines of Blaschko and these can continue as linear intraoral lesions, as in mucosal papillomatosis.
PTM
Acetylation at Lys-104 prevents interaction with guanine nucleotide exchange factors (GEFs).
Ubiquitinated by the BCR(LZTR1) E3 ubiquitin ligase complex at Lys-170 in a non-degradative manner, leading to inhibit Ras signaling by decreasing Ras association with membranes.
(Microbial infection) Glucosylated at Thr-35 by P.sordellii toxin TcsL.

Anti-KRAS antibodies

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Target: KRAS
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey, Fruit Fly
Clone: CBFYH-2611
Application*: WB
Target: KRAS
Host: Rabbit
Specificity: Human, Mouse, Rat
Clone: D8H7
Application*: WB
Target: KRAS
Host: Mouse
Antibody Isotype: IgG2c
Specificity: Human
Clone: 8BA15
Application*: E, WB
Target: KRAS
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 8BA14
Application*: E, WB
Target: KRAS
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: D8H7
Application*: WB
Target: KRAS
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: D2H12
Application*: WB
Target: KRAS
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: D2C1
Application*: WB
Target: KRAS
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4E2
Application*: WB, E
Target: KRAS
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Rat, Human, Mouse
Clone: 234-4.2
Application*: C, P, IP, WB
Target: KRAS
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYH-2610
Application*: IH, WB
Target: KRAS
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Horse, Cattle, Dog, Pig
Clone: C-4
Application*: WB, IP, IC, IF
Target: KRAS
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: D2C1
Application*: WB
Target: KRAS
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat, Mouse
Clone: M337
Application*: WB, E, ICC
Target: KRAS
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: RAS10
Application*: F
Target: KRAS
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBLY1-139
Application*: WB, IP, IC
Target: KRAS
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1D1
Application*: WB
Target: KRAS
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: 1E4-1B10
Application*: E, WB
Target: KRAS
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 2C1
Application*: WB
Target: KRAS
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3B10-2F2
Application*: E, IF, WB
Target: KRAS
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3B12
Application*: WB
Target: KRAS
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 4F3
Application*: WB
Target: KRAS
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4F6
Application*: WB
Target: KRAS
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 8B4
Application*: WB
Target: KRAS
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9.13
Application*: IF, P, IP, WB
Target: KRAS
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: AT2F8
Application*: E, F, IC/IF, WB
Target: KRAS
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: F132-62
Application*: IC, IF, C, P, IP
Target: KRAS
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: PAT2F8AT
Application*: IA, WB, IC, IF, F
Target: KRAS
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBCNR-231
Application*: WB, IP, ICC
Target: KRAS
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Chicken, Dog, Mouse, Rat
Clone: 18/Ras
Application*: WB, IF, IH, IP
Target: KRAS
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 1A6.2
Application*: WB, P
Target: KRAS
Host: Rat
Antibody Isotype: IgG2b
Specificity: Human
Clone: 342404
Application*: WB
Target: KRAS
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: 5M52
Application*: WB
Target: KRAS
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse
Clone: 6D7C6
Application*: WB, E, P
Target: KRAS
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: AT2G9
Application*: E, WB
Target: KRAS
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Zebrafish
Clone: CBCNR-232
Application*: WB, IP, F
Target: KRAS
Host: Rat
Antibody Isotype: IgG1
Specificity: Rat
Clone: Y13-259
Application*: WB, IP
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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