MAPK7

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Full Name

Mitogen-Activated Protein Kinase 7

Function

Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction.

Biological Process

cAMP-mediated signaling1 PublicationNAS:BHF-UCL
Cell cycleIEA:UniProtKB-KW
Cell differentiationIEA:UniProtKB-KW
Cellular response to growth factor stimulusManual Assertion Based On ExperimentIGI:BHF-UCL
Cellular response to hydrogen peroxideManual Assertion Based On ExperimentIMP:BHF-UCL
Cellular response to laminar fluid shear stressManual Assertion Based On ExperimentIMP:BHF-UCL
Cellular response to transforming growth factor beta stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Intracellular signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of calcineurin-NFAT signaling cascadeIEA:Ensembl
Negative regulation of cyclic-nucleotide phosphodiesterase activity1 PublicationNAS:BHF-UCL
Negative regulation of endothelial cell apoptotic processManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of extrinsic apoptotic signaling pathway in absence of ligandManual Assertion Based On ExperimentIGI:BHF-UCL
Negative regulation of heterotypic cell-cell adhesionManual Assertion Based On ExperimentIGI:BHF-UCL
Negative regulation of inflammatory responseManual Assertion Based On ExperimentTAS:BHF-UCL
Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of response to cytokine stimulusManual Assertion Based On ExperimentIGI:BHF-UCL
Peptidyl-serine phosphorylationIEA:Ensembl
Positive regulation of protein metabolic processManual Assertion Based On ExperimentIGI:BHF-UCL
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIGI:BHF-UCL
Positive regulation of transcription from RNA polymerase II promoter in response to stressManual Assertion Based On ExperimentIMP:BHF-UCL
Regulation of angiogenesisIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Cytoplasm
Nucleus
Nucleus, PML body
Translocates to the nucleus upon activation.

PTM

Dually phosphorylated on Thr-219 and Tyr-221, which activates the enzyme (By similarity).
Autophosphorylated in vitro on threonine and tyrosine residues when the C-terminal part of the kinase, which could have a regulatory role, is absent.