MLF1

This gene encodes an oncoprotein which is thought to play a role in the phenotypic determination of hemopoetic cells. Translocations between this gene and nucleophosmin have been associated with myelodysplastic syndrome and acute myeloid leukemia.

Full Name

MYELOID LEUKEMIA FACTOR 1

Function

Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.

Biological Process

Cell cycle Source: UniProtKB-KW
Myeloid progenitor cell differentiation Source: UniProtKB
Regulation of cell cycle G1/S phase transition Source: UniProtKB
Regulation of signal transduction by p53 class mediator Source: UniProtKB
Regulation of transcription, DNA-templated Source: GO_Central
Transcription, DNA-templated Source: UniProtKB

Cellular Location

Nucleus
Cytoskeleton
cilium basal body
Cytoplasm
Other locations
cilium
Note: Shuttles between the cytoplasm and nucleus.

Involvement in disease

A chromosomal aberration involving MLF1 is a cause of myelodysplastic syndrome (MDS). Translocation t(3;5)(q25.1;q34) with NPM1/NPM.

PTM

Phosphorylation is required for binding to YWHAZ.