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NFS1

Iron-sulfur clusters are required for the function of many cellular enzymes. The proteins encoded by this gene supply inorganic sulfur to these clusters by removing the sulfur from cysteine, creating alanine in the process. This gene uses alternate in-frame translation initiation sites to generate mitochondrial forms and cytoplasmic/nuclear forms. Selection of the alternative initiation sites is determined by the cytosolic pH. The encoded proteins belong to the class-V family of pyridoxal phosphate-dependent aminotransferases. Alternatively spliced transcript variants have been described.
Full Name
NFS1, Cysteine Desulfurase
Function
Catalyzes the removal of elemental sulfur from cysteine to produce alanine (PubMed:18650437).
It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters. May be involved in the biosynthesis of molybdenum cofactor (PubMed:18650437).
Biological Process
[2Fe-2S] cluster assemblyIEA:InterPro
Iron incorporation into metallo-sulfur clusterManual Assertion Based On ExperimentIDA:HGNC-UCL
Iron-sulfur cluster assemblyManual Assertion Based On ExperimentIBA:GO_Central
Mo-molybdopterin cofactor biosynthetic processIEA:UniProtKB-KW
Cellular Location
Isoform Mitochondrial
Mitochondrion
Isoform Cytoplasmic
Cytoplasm
Nucleus
Involvement in disease
Combined oxidative phosphorylation deficiency 52 (COXPD52):
An autosomal recessive mitochondrial disorder with onset in infancy, characterized by lactic acidemia, hypotonia, respiratory chain complex II and III deficiency, multisystem organ failure and abnormal mitochondria.
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Anti-NFS1 antibodies

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Mouse Anti-NFS1 Recombinant Antibody (CBWJN-1386) (CBMAB-N2324-WJ)

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Target: NFS1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBWJN-1386
Application*: WB
Datasheet SDS

Mouse Anti-NFS1 Recombinant Antibody (5D1) (CBMAB-N2323-WJ)

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Target: NFS1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 5D1
Application*: WB, IH
Datasheet SDS

Mouse Anti-NFS1 Recombinant Antibody (2H5) (CBMAB-N2322-WJ)

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Target: NFS1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 2H5
Application*: WB, IH
Datasheet SDS

Mouse Anti-NFS1 Recombinant Antibody (1D5) (CBMAB-N2321-WJ)

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Target: NFS1
Host: Mouse
Specificity: Human
Clone: 1D5
Application*: E, WB
Datasheet SDS

Mouse Anti-NFS1 Recombinant Antibody (CBWJN-0317) (CBMAB-N0338-WJ)

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Target: NFS1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-0317
Application*: DB, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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