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NR1H2

The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).[supplied by OMIM, Jan 2010]
Full Name
NR1H2
Function
Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:25661920).
Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity).
Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis (By similarity).
Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles (By similarity).
Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators (By similarity).
Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957).
Biological Process
Cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Cholesterol homeostasisISS:UniProtKB
Negative regulation of cholesterol storageManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of cold-induced thermogenesisBy SimilarityISS:YuBioLab
Negative regulation of gene expressionIEA:Ensembl
Negative regulation of interferon-gamma-mediated signaling pathway1 PublicationNAS:BHF-UCL
Negative regulation of lipid transportManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of macrophage derived foam cell differentiation1 PublicationIC:BHF-UCL
Negative regulation of pinocytosisManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of proteolysisIEA:Ensembl
Negative regulation of response to endoplasmic reticulum stressISS:UniProtKB
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:HGNC-UCL
Phosphatidylcholine acyl-chain remodelingISS:UniProtKB
Positive regulation of cellular protein metabolic processManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of cholesterol effluxManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of cholesterol transportManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of fatty acid biosynthetic processManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of gene expressionIEA:Ensembl
Positive regulation of high-density lipoprotein particle assemblyIEA:Ensembl
Positive regulation of lipid storageIEA:Ensembl
Positive regulation of lipoprotein lipase activityManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of miRNA transcriptionIEA:Ensembl
Positive regulation of pancreatic juice secretionIEA:Ensembl
Positive regulation of secretion of lysosomal enzymesIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of triglyceride biosynthetic processManual Assertion Based On ExperimentIMP:BHF-UCL
Response to nutrient levelsIEA:Ensembl
Retinoic acid receptor signaling pathwayIEA:Ensembl
Cellular Location
Nucleus
PTM
Sumoylated by SUMO2 at Lys-409 and Lys-447 during the hepatic acute phase response, leading to promote interaction with GPS2 and prevent N-Cor corepressor complex dissociation.

Anti-NR1H2 antibodies

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Target: NR1H2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Common fruit fly
Clone: 1D11
Application*: IP, M
Target: NR1H2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: K8917
Application*: WB, IP, E
Target: NR1H2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJL-246
Application*: WB, IP, IF, E
Target: NR1H2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: CBYJL-245
Application*: WB
Target: NR1H2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: D6M9D
Application*: WB
Target: NR1H2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2H2-H3
Application*: E, WB
Target: NR1H2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Pig
Clone: 1E12B10
Application*: E, WB
Target: NR1H2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1E1
Application*: E, IF, WB
Target: NR1H2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Rat
Clone: CBYCL-618
Application*: WB, E, F, IC, IF
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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