SLITRK6

This gene encodes a member of the SLITRK protein family. Members of this family are integral membrane proteins that are characterized by two N-terminal leucine-rich repeat (LRR) domains and a C-terminal region that shares homology with trk neurotrophin receptors. This protein functions as a regulator of neurite outgrowth required for normal hearing and vision. Mutations in this gene are a cause of myopia and deafness.

Full Name

SLIT And NTRK Like Family Member 6

Function

Regulator of neurite outgrowth required for normal hearing and vision.

Biological Process

Biological Process adult locomotory behaviorIEA:Ensembl
Biological Process auditory behaviorIEA:Ensembl
Biological Process auditory receptor cell morphogenesisIEA:Ensembl
Biological Process axonogenesisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cochlea developmentIEA:Ensembl
Biological Process innervationIEA:Ensembl
Biological Process lens development in camera-type eyeIEA:Ensembl
Biological Process linear vestibuloocular reflexIEA:Ensembl
Biological Process multicellular organism growthIEA:Ensembl
Biological Process positive regulation of synapse assemblyManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of presynapse assemblyIEA:InterPro
Biological Process sensory perception of soundIEA:UniProtKB-KW
Biological Process startle responseIEA:Ensembl
Biological Process synapse assemblyManual Assertion Based On ExperimentIMP:MGI
Biological Process vestibulocochlear nerve developmentIEA:Ensembl
Biological Process visual perceptionIEA:UniProtKB-KW

Cellular Location

Cell membrane

Involvement in disease

Deafness and myopia (DFNMYP):
An autosomal recessive disorder characterized by prelingual sensorineural hearing loss associated with high myopia.

Topology

Extracellular: 27-608
Helical: 609-629
Cytoplasmic: 630-841