TIPIN

The protein encoded by this gene is part of the replisome complex, a group of proteins that support DNA replication. It binds TIM, which is involved in circadian rhythm regulation, and aids in protecting cells against DNA damage and stress. Two pseudogenes and two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

TIPIN Gene(Protein Coding) TIMELESS Interacting Protein

Plays an important role in the control of DNA replication and the maintenance of replication fork stability (PubMed:23359676, PubMed:35585232, PubMed:17102137).
Important for cell survival after DNA damage or replication stress (PubMed:17116885).
May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light (PubMed:17296725).
Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress (PubMed:23359676, PubMed:35585232, PubMed:17102137, PubMed:17116885, PubMed:17296725).

Biological Process cell cycle phase transitionSource:BHF-UCL1 Publication
Biological Process cell divisionSource:UniProtKB-KW
Biological Process DNA replication checkpoint signalingSource:HGNC-UCL1 Publication
Biological Process mitotic intra-S DNA damage checkpoint signalingSource:HGNC-UCL1 Publication
Biological Process positive regulation of cell population proliferationSource:HGNC-UCL1 Publication
Biological Process regulation of nuclear cell cycle DNA replicationSource:HGNC-UCL1 Publication
Biological Process replication fork arrestSource:GO_Central1 Publication
Biological Process replication fork protectionSource:GO_Central1 Publication
Biological Process response to UVSource:Ensembl

Cytoplasm
Nucleus