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TPT1

This gene encodes a protein that is a regulator of cellular growth and proliferation. Its mRNA is highly structured and contains an oligopyrimidine tract (5'-TOP) in its 5' untranslated region that functions to repress its translation under quiescent conditions. The encoded protein is involved in a variety of cellular pathways, including apoptosis, protein synthesis and cell division. It binds to and stabilizes microtubules, and removal of this protein through phosphorylation is required for progression through mitotic and meiotic cell divisions. This gene is known to play a role in carcinogenesis, and is upregulated in some cancer cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
Full Name
TPT1 Gene(Protein Coding) Tumor Protein, Translationally-Controlled 1
Function
Involved in calcium binding and microtubule stabilization.
Biological Process
Biological Process calcium ion transport Source:UniProtKB1 Publication
Biological Process cellular calcium ion homeostasis Source:UniProtKB1 Publication
Biological Process negative regulation of apoptotic process Source:UniProtKB1 Publication
Biological Process negative regulation of ectoderm development Source:Ensembl
Biological Process negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source:MGI1 Publication
Biological Process regulation of apoptotic process Source:UniProtKB1 Publication
Biological Process response to virus Source:UniProtKB1 Publication
Biological Process stem cell population maintenance Source:Ensembl
Cellular Location
Cytoplasm
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Anti-TPT1 antibodies

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Mouse Anti-TPT1 Recombinant Antibody (3C7) (CBMAB-A9467-LY)

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Target: TPT1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: 3C7
Application*: WB, E
Datasheet SDS

Mouse Anti-TPT1 Recombinant Antibody (2C4) (CBMAB-A9466-LY)

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Target: TPT1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2C4
Application*: WB, E
Datasheet SDS

Rabbit Anti-TPT1 Recombinant Antibody (CBYJT-4440) (CBMAB-T3934-YJ)

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Target: TPT1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: CBYJT-4440
Application*: WB
Datasheet SDS

Mouse Anti-TPT1 Recombinant Antibody (CBYJT-4437) (CBMAB-T3931-YJ)

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Target: TPT1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBYJT-4437
Application*: IP, P, WB
Datasheet SDS

Mouse Anti-TPT1 Recombinant Antibody (CBYJT-4436) (CBMAB-T3930-YJ)

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Target: TPT1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBYJT-4436
Application*: WB, IC
Datasheet SDS

Mouse Anti-TPT1 Recombinant Antibody (CBYJT-4435) (CBMAB-T3929-YJ)

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Target: TPT1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-4435
Application*: IC, P, E, WB
Datasheet SDS

Mouse Anti-TPT1 Recombinant Antibody (CBYJT-4434) (CBMAB-T3928-YJ)

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Target: TPT1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-4434
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-TPT1 Recombinant Antibody (CBYJT-4433) (CBMAB-T3927-YJ)

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Target: TPT1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-4433
Application*: E, WB
Datasheet SDS

Mouse Anti-TPT1 Recombinant Antibody (CBYJT-4432) (CBMAB-T3926-YJ)

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Target: TPT1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYJT-4432
Application*: E, WB
Datasheet SDS

Mouse Anti-TPT1 Recombinant Antibody (CBYJT-4431) (CBMAB-T3925-YJ)

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Target: TPT1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-4431
Application*: E, IC, IH, WB
Datasheet SDS

Mouse Anti-TPT1 Recombinant Antibody (CBYJT-4430) (CBMAB-T3924-YJ)

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Target: TPT1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-4430
Application*: E
Datasheet SDS

Mouse Anti-TPT1 Recombinant Antibody (CBFYH-2807) (CBMAB-H3871-FY)

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Target: TPT1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2807
Application*: IH, WB
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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