UTS2

This gene encodes a mature peptide that is an active cyclic heptapeptide absolutely conserved from lamprey to human. The active peptide acts as a vasoconstrictor and is expressed only in brain tissue. Despite the gene family name similarity, this gene is not homologous to urocortin, a member of the sauvagine/corticotropin-releasing factor/urotensin I family. Most of the proprotein is cleaved to make the mature peptide. Transcript variants encoding different preproprotein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Full Name

Urotensin 2

Function

Highly potent vasoconstrictor.

Biological Process

Biological Process blood vessel diameter maintenance Source:Ensembl
Biological Process chemical synaptic transmission Source:ProtInc1 Publication
Biological Process muscle contraction Source:ProtInc1 Publication
Biological Process negative regulation of blood pressure Source:Ensembl
Biological Process negative regulation of glomerular filtration Source:Ensembl
Biological Process negative regulation of heart rate Source:Ensembl
Biological Process negative regulation of insulin secretion Source:Ensembl
Biological Process negative regulation of renal sodium excretion Source:Ensembl
Biological Process negative regulation of urine volume Source:Ensembl
Biological Process positive regulation of angiogenesis Source:Ensembl
Biological Process positive regulation of blood pressure Source:Ensembl
Biological Process positive regulation of cell differentiation Source:Ensembl
Biological Process positive regulation of circadian sleep/wake cycle, REM sleep Source:Ensembl
Biological Process positive regulation of circadian sleep/wake cycle, wakefulness Source:Ensembl
Biological Process positive regulation of collagen biosynthetic process Source:Ensembl
Biological Process positive regulation of cytosolic calcium ion concentration Source:Ensembl
Biological Process positive regulation of fibroblast migration Source:Ensembl
Biological Process positive regulation of fibroblast proliferation Source:Ensembl
Biological Process positive regulation of heart rate Source:Ensembl
Biological Process positive regulation of synaptic transmission, cholinergic Source:Ensembl
Biological Process regulation of blood pressure Source:GO_Central1 Publication
Biological Process response to hypoxia Source:Ensembl
Biological Process response to testosterone Source:Ensembl
Biological Process response to xenobiotic stimulus Source:Ensembl

Cellular Location

Secreted