WNT5B

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 94% and 80% amino acid identity to the mouse Wnt5b protein and the human WNT5A protein, respectively. Alternative splicing of this gene generates 2 transcript variants.

Full Name

Wnt Family Member 5B

Function

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).

Biological Process

Biological Process canonical Wnt signaling pathway Source:GO_Central1 Publication
Biological Process cell fate commitment Source:GO_Central1 Publication
Biological Process cellular response to retinoic acid Source:UniProtKB
Biological Process chondrocyte differentiation Source:UniProtKB1 Publication
Biological Process fat cell differentiation Source:UniProtKB1 Publication
Biological Process lens fiber cell development Source:BHF-UCLBy Similarity
Biological Process muscle cell differentiation Source:UniProtKB
Biological Process neuron differentiation Source:UniProtKB
Biological Process positive regulation of cell migration Source:UniProtKB1 Publication
Biological Process positive regulation of convergent extension involved in gastrulation Source:UniProtKB
Biological Process positive regulation of non-canonical Wnt signaling pathway Source:UniProtKB
Biological Process wound healing Source:Ensembl

Cellular Location

Secreted, extracellular space, extracellular matrix

PTM

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.