Mouse Anti-DSTN Recombinant Antibody (2E10) (CBMAB-D1823-YC)

Name: Mouse Anti-DSTN Recombinant Antibody (2E10)
SKU: CBMAB-D1823-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2E10

Application

FC, IHC, WB

Immunogen

Full length recombinant protein of human DSTN produced in HEK293T cells.

Host Species

Mouse

Specificity

Human, Dog, Monkey, Mouse

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:1,000-1:2,000
IHC	1:100
FC	1:100

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

BSA & Glycerol & PBS

Preservative

Sodium Azide

Concentration

1 mg/ml

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Destrin, Actin Depolymerizing Factor

Introduction

DSTN belongs to the actin-binding proteins ADF family. This family of proteins is responsible for enhancing the turnover rate of actin in vivo. This gene encodes the actin depolymerizing protein that severs actin filaments (F-actin) and binds to actin monomers (G-actin).

Entrez Gene ID

Human	11034
Dog	477147
Monkey	695969

UniProt ID

Human	P60981
Dog	J9P1J5
Monkey	H9EM17

Alternative Names

Destrin, Actin Depolymerizing Factor; Actin-Depolymerizing Factor; ACTDP; ADF; BA462D18.2 (Destrin (Actin Depolymerizing Factor ADF) (ACTDP)); Destrin (Actin Depolymerizing Factor);

Research Area

Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner.

Biological Process

Actin filament depolymerization Source: UniProtKB
Actin filament fragmentation Source: GO_Central
Actin filament severing Source: GO_Central
Actin polymerization or depolymerization Source: ProtInc
Cell motility Source: GO_Central
Positive regulation of actin filament depolymerization Source: Ensembl

Cellular Location

Actin cytoskeleton; Cortical actin cytoskeleton; Extracellular exosome; Cytoplasm

PTM

ISGylated.

Liao, K. A., Rangarajan, K. V., Bai, X., Taylor, J. M., & Mack, C. P. (2021). The actin depolymerizing factor destrin serves as a negative feedback inhibitor of smooth muscle cell differentiation. American Journal of Physiology-Heart and Circulatory Physiology, 321(5), H893-H904.

Talabot-Ayer, D., Mermoud, L., Borowczyk, J., Drukala, J., Wolnicki, M., Modarressi, A., ... & Palmer, G. (2019). Interleukin-38 interacts with destrin/actin-depolymerizing factor in human keratinocytes. PLoS One, 14(11), e0225782.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-DSTN Recombinant Antibody (2F7) (CAT#: CBMAB-D1825-YC)

Mouse Anti-DSTN Recombinant Antibody (1D8) (CAT#: CBMAB-D1820-YC)

Mouse Anti-DSTN Recombinant Antibody (1G8) (CAT#: V2LY-0425-LY1017)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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