Mouse Anti-FCN1 Recombinant Antibody (CBXF-2930) (CBMAB-F3637-CQ)

Name: Mouse Anti-FCN1 Recombinant Antibody (CBXF-2930)
SKU: CBMAB-F3637-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXF-2930

Application

ELISA

Immunogen

Recombinant protein corresponding to human M-Ficolin (aa95- 314)

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Preservative

15 mM sodium azide

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Ficolin 1

Introduction

The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins. However, all these proteins recognize different targets, and are functionally distinct. Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity.

Entrez Gene ID

2219

UniProt ID

O00602

Alternative Names

Ficolin 1; Ficolin (Collagen/Fibrinogen Domain-Containing) 1; Ficolin-Alpha; Ficolin-A; M-Ficolin; FCNM; Ficolin (Collagen/Fibrinogen Domain Containing) 1; Collagen/Fibrinogen Domain-Containing Protein 1; Ficolin-1;

Research Area

Extracellular lectin functioning as a pattern-recognition receptor in innate immunity. Binds the sugar moieties of pathogen-associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8 (PubMed:21037097).

Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage.

Biological Process

Cell surface pattern recognition receptor signaling pathway Source: UniProtKB
Complement activation, lectin pathway Source: GO_Central
G protein-coupled receptor signaling pathway Source: UniProtKB
Negative regulation of viral entry into host cell Source: UniProtKB
Positive regulation of interleukin-8 production Source: UniProtKB
Protein localization to cell surface Source: UniProtKB
Recognition of apoptotic cell Source: UniProtKB

Cellular Location

Secreted; Cell membrane. Found on the monocyte and granulocyte surface (PubMed:20400674).

Xue, D., Tabib, T., Morse, C., Yang, Y., Domsic, R. T., Khanna, D., & Lafyatis, R. (2022). Expansion of Fcγ Receptor IIIa–Positive Macrophages, Ficolin 1–Positive Monocyte‐Derived Dendritic Cells, and Plasmacytoid Dendritic Cells Associated With Severe Skin Disease in Systemic Sclerosis. Arthritis & Rheumatology, 74(2), 329-341.

Luo, J., Wang, T., Wang, X., Shi, Y., Zhang, Y., Tian, J., & Gong, Y. (2022). Ficolin-3 may act as a tumour suppressor by recognising O-GlcNAcylation site in hepatocellular carcinoma. Medical Hypotheses, 166, 110899.

Li, Y., You, E. Q., Lin, W. H., Liu, X. N., Shen, D. P., Zhang, X. L., ... & Li, H. M. (2021). Association of ficolin‐1 and ficolin‐3 gene variation and pulmonary tuberculosis susceptibility in a Chinese population. Journal of Clinical Laboratory Analysis, 35(4), e23732.

Elkoumi, M. A., Abdellatif, S. H., Mohamed, F. Y., Sherif, A. H., Elashkar, S. S., Saleh, R. M., ... & Zeidan, N. M. (2020). Ficolin‐1 gene (FCN1)− 144 C/A polymorphism is associated with adverse outcome of severe pneumonia in the under‐five Egyptian children: A multicenter study. Pediatric Pulmonology, 55(5), 1175-1183.

Pieczarka, C., Andrade, F. A., Catarino, S. J., Lidani, K. C. F., Bavia, L., Tizzot, R., ... & de Messias-Reason, I. J. (2020). Ficolin-1 and ficolin-3 polymorphisms and susceptibility to rheumatoid arthritis. Autoimmunity, 53(7), 400-407.

Katayama, M., Ota, K., Nagi-Miura, N., Ohno, N., Yabuta, N., Nojima, H., ... & Hirano, T. (2019). Ficolin-1 is a promising therapeutic target for autoimmune diseases. International immunology, 31(1), 23-32.

Catarino, S. J., Andrade, F. A., Boldt, A. B. W., Guilherme, L., & Messias-Reason, I. J. (2018). Sickening or healing the heart? The association of ficolin-1 and rheumatic fever. Frontiers in immunology, 9, 3009.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

FCN1 Matched Antibody Pair (420) (CAT#: APMAB-420LY)

FCN1 Matched Antibody Pair (421) (CAT#: APMAB-421LY)

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Isotype control

For research use only. Not intended for any clinical use.

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